Unconjugated methoxylated catecholamine metabolites in human saliva. Quantitation methodology and comparison with plasma levels.
Unconjugated methoxylated catecholamine metabolites in human saliva. Quantitation methodology and comparison with plasma levels.
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人唾液中未结合的甲氧基化儿茶酚胺代谢物。
DOI：
10.1002/bmc.1130030509
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gerhardt,GA
中科院分区：
文献类型：
--
作者：
Drebing,CJ;Freedman,R;Waldo,M;Gerhardt,GA
建立了一种同时提取和定量血浆中儿茶酚胺代谢物香草扁桃酸（VMA）、3-甲氧基-4-羟基苯基乙二醇（MHPG）和高香草酸（HVA）的高效液相色谱-电化学检测方法，并应用于人唾液的研究。对于每种代谢物，该测定法的平均变异系数均低于3%。测定了28名正常人咀嚼刺激前后血浆VMA、MHPG和HVA的含量，并与唾液中VMA、MHPG和HVA的含量进行了比较。血浆和唾液中MHPG和HVA之间存在显著相关性，而血浆和唾液中VMA之间无相关性。唾液MHPG和HVA可以重复测定，并可能是有用的工具，用于指示中枢和外周儿茶酚胺代谢的变化。
A newly developed method for the simultaneous extraction and quantitation of the unconjugated levels of the catecholamine metabolites vanilmandelic acid (VMA), 3‐methoxy‐4‐hydroxyphenylethylene glycol (MHPG) and homovanillic acid (HVA) in plasma by high performance liquid chromatography with electrochemical detection was modified and applied to studies of human saliva. The assay had a mean coefficient of variation under 3% for each of the metabolites. Levels of plasma VMA, MHPG and HVA were measured in 28 normal subjects and compared to their saliva levels, obtained before and after stimulation by mastication. Significant correlations were found between plasma and saliva MHPG and HVA, but there was no correlation between plasma and saliva VMA. Salivary MHPG and HVA can be reproducibly assayed and may be useful tools for indications of changes in central and peripheral catecholamine metabolism.
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影响因子：
6.6
作者：
FREEDMAN, R;ADLER, LE;FRANKS, R
通讯作者：
FRANKS, R
采用电化学检测器高效液相色谱 (HPLC-EC) 测定血浆中的 3-甲氧基-4-羟基苯乙酸 (HVA)。
影响因子：
2.9
作者：
J. Javaid;T. Liu;J. Maas;J. Davis
通讯作者：
J. Davis
影响因子：
7.6
作者：
FERGUSON, DB
通讯作者：
FERGUSON, DB
抗精神病药维持和停药期间血浆高香草酸和迟发性运动障碍
影响因子：
11.3
作者：
D. Kirch;S. Hattox;J. Bell;R. Murphy;R. Freedman
通讯作者：
R. Freedman
血浆高香草酸浓度和精神分裂症的严重程度。
DOI：
10.1126/science.3975630
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davis,KL;Davidson,M;Mohs,RC;Kendler,KS;Davis,BM;Johns,CA;DeNigris,Y;Horvath,TB
通讯作者：
Horvath,TB