Sensitive indicators of inorganic mercury toxicity.

Sensitive indicators of inorganic mercury toxicity.
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无机汞毒性的敏感指标。

DOI:
10.1080/00039896.1986.9938335
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发表时间:
1986
期刊:
Archives of environmental health
影响因子:
--
通讯作者:
Cinotti,A
Cinotti,A
中科院分区:
--
文献类型:
--
作者:
Rosenman,KD;Valciukas,JA;Glickman,L;Meyers,BR;Cinotti,A

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一家生产无机汞化合物的化工厂的 42 名工人接受了神经、肾病和眼科毒性评估。尽管血液和尿液中的汞含量升高,但体格检查、血液化学和尿液分析等常规临床检测总体正常。常规检查中的这些发现与当针对已知受汞影响的器官系统时发现的神经心理症状、尿液 n-乙酰 B-D-氨基葡萄糖苷酶 (NAG) 水平升高、运动神经传导速度降低以及裂隙灯检查中发现晶状体混浊的主诉形成鲜明对比。常规医学筛查中需要纳入更敏感但客观的毒性指标,以帮助诊断神经心理症状的病因,并防止接触汞的工人出现长期后遗症。
Forty-two workers from a chemical plant producing inorganic mercury compounds were evaluated for neurologic, nephrotic, and ophthalomogic toxicity. Despite elevated blood and urinary mercury levels, routine clinical testing such as physical examination, blood chemistries, and urinalysis were generally normal. These findings from the routine examination are in contrast to the complaints of neuropsychological symptoms, elevated urinary n-acetyl B-D-glucosaminidase (NAG) levels, decreased motor nerve conduction velocities, and the presence of lenticular opacities on slit-lamp examination that were found, when organ systems known to be affected by mercury were targeted. More sensitive but objective indicators of toxicity need to be included in routine medical screening so as to help diagnose the etiology of neuropsychological symptoms and prevent long-term sequelae in workers exposed to mercury.
“非必需”氮:人类生长的限制因素。
DOI: --
发表时间: 1962
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影响因子: --
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