Circulating cytokines and alarmins associated with placental inflammation in high-risk pregnancies.
Circulating cytokines and alarmins associated with placental inflammation in high-risk pregnancies.
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DOI：
10.1111/aji.12274
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Jones RL
中科院分区：
文献类型：
--
作者：
Girard S;Heazell AE;Derricott H;Allan SM;Sibley CP;Abrahams VM;Jones RL
怀孕期间的炎症对胎盘和胎儿有毁灭性的后果。对这些事件的了解不完全，从而妨碍了筛查和治疗。研究了胎盘功能障碍高危妊娠绒毛组织的炎症特征，并与无并发症的妊娠进行了比较。在胎动减少（RFM）的情况下，在匹配的母体血清样本中评估全身炎症特征。RFM妊娠的胎盘具有独特的炎症特征，其特征为白细胞介素（IL）-1受体拮抗剂增加和IL-10表达减少，同时胎盘巨噬细胞数量增加。这种异常的细胞因子谱在RFM的母体血清中是明显的，同时alarmins（尿酸、HMGB 1、无细胞胎儿DNA）水平也升高。母胎界面的这种独特的炎症特征反映在母体血清中，可以代表胎盘炎症的生物标志物，并可以提供新的治疗选择，以保护胎盘和胎儿免受不利的母体环境的影响。
Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. The inflammatory profile of villous tissue was studied in pregnancies at high-risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM). Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)-1 receptor antagonist and decreased IL-10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell-free fetal DNA). This distinct inflammatory profile at the maternal-fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.
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DOI：
10.1530/rep-13-0232
发表时间：
2013
期刊：
Reproduction (Cambridge, England)
影响因子：
--
作者：
Adams Waldorf KM;McAdams RM
通讯作者：
McAdams RM
DOI：
10.1016/0002-9378(88)90090-7
发表时间：
1988-04-01
影响因子：
9.8
作者：
DAVEY, DA;MACGILLIVRAY, I
通讯作者：
MACGILLIVRAY, I
影响因子：
4.4
作者：
Liu, Hongqi;Redline, Raymond W.;Han, Yiping W.
通讯作者：
Han, Yiping W.
影响因子：
3.7
作者：
Mulla, Melissa J.;Salmon, Jane E.;Abrahams, Vikki M.
通讯作者：
Abrahams, Vikki M.
影响因子：
3.7
作者：
Warrander, Lynne K.;Batra, Gauri;Heazell, Alexander E. P.
通讯作者：
Heazell, Alexander E. P.