Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.
Pharmacogenetics of Type 2 Diabetes-Progress and Prospects.
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DOI：
10.3390/ijms21186842
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发表时间：
2020-09-18
影响因子：
5.6
通讯作者：
Glotov AS
中科院分区：
文献类型：
--
作者：
Nasykhova YA;Tonyan ZN;Mikhailova AA;Danilova MM;Glotov AS
2型糖尿病(T2D)是由胰岛素抵抗和胰岛素分泌进行性减少引起的一种慢性代谢性疾病，可导致糖利用受损、血脂异常、高胰岛素血症和进行性胰岛β细胞功能障碍。2型糖尿病的发病率在全球范围内呈上升趋势，目前T2D已成为一种全球性的流行病。众所周知，T2D药物作用的个体间差异，如双胍类、磺脲类/美格列酮类、DPP-4抑制剂/GLP1R激动剂和SGLT-2抑制剂，除其他因素外，可能是由遗传因素引起的。药物遗传学的发现可能有助于确定新的药物靶点，并深入了解疾病的原因及其生理过程，从而为制定量身定制或精确治疗的算法提供机会。本文的目的是总结T2D药物遗传学的最新进展和发现，并讨论在患者对治疗的反应中限制遗传变异知识进一步积累的因素，以提高T2D的个性化治疗。
Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction. The incidence of type 2 diabetes mellitus is increasing worldwide and nowadays T2D already became a global epidemic. The well-known interindividual variability of T2D drug actions such as biguanides, sulfonylureas/meglitinides, DPP-4 inhibitors/GLP1R agonists and SGLT-2 inhibitors may be caused, among other things, by genetic factors. Pharmacogenetic findings may aid in identifying new drug targets and obtaining in-depth knowledge of the causes of disease and its physiological processes, thereby, providing an opportunity to elaborate an algorithm for tailor or precision treatment. The aim of this article is to summarize recent progress and discoveries for T2D pharmacogenetics and to discuss the factors which limit the furthering accumulation of genetic variability knowledge in patient response to therapy that will allow improvement the personalized treatment of T2D.
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作者：
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通讯作者：
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发表时间：
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影响因子：
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