PARma: identification of microRNA target sites in AGO-PAR-CLIP data.

PARma: identification of microRNA target sites in AGO-PAR-CLIP data.
复制标题

DOI:
10.1186/gb-2013-14-7-r79
复制
发表时间:
2013-07-29
期刊:
影响因子:
12.3
通讯作者:
Zimmer R
Zimmer R
中科院分区:
生物学1区
文献类型:
--
作者:
Erhard F;Dölken L;Jaskiewicz L;Zimmer R

文献摘要

参考文献

被引文献

相似文献

PARma 是一款用于 AGO-PAR-CLIP 实验的完整数据分析软件,可识别 microRNA 的靶位点以及与这些位点结合的 microRNA。它将实验的具体特征整合到生成模型中。该模型和一种新颖的模式发现工具迭代地应用于数据,以估计种子活动概率、聚类置信度得分并分配最可能的 microRNA。基于差分 PAR-CLIP 分析以及与 RIP-Chip 数据的比较,我们表明 PARma 比现有方法更准确。 PARma 可从 http://www.bio.ifi.lmu.de/PARma 获取
PARma is a complete data analysis software for AGO-PAR-CLIP experiments to identify target sites of microRNAs as well as the microRNA binding to these sites. It integrates specific characteristics of the experiments into a generative model. The model and a novel pattern discovery tool are iteratively applied to data to estimate seed activity probabilities, cluster confidence scores and to assign the most probable microRNA. Based on differential PAR-CLIP analysis and comparison to RIP-Chip data, we show that PARma is more accurate than existing approaches. PARma is available from http://www.bio.ifi.lmu.de/PARma
DOI: 10.1093/bioinformatics/btq363
发表时间: 2010-09-15
期刊: Bioinformatics (Oxford, England)
影响因子: --
作者:
Erhard F;Zimmer R
通讯作者: Zimmer R
DOI: 10.1016/j.cell.2010.03.009
发表时间: 2010-04-02
期刊: Cell
影响因子: 64.5
作者:
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者: Tuschl T
DOI: 10.1093/nar/gkr1055
发表时间: 2012-01
影响因子: 14.9
作者:
Dreszer TR;Karolchik D;Zweig AS;Hinrichs AS;Raney BJ;Kuhn RM;Meyer LR;Wong M;Sloan CA;Rosenbloom KR;Roe G;Rhead B;Pohl A;Malladi VS;Li CH;Learned K;Kirkup V;Hsu F;Harte RA;Guruvadoo L;Goldman M;Giardine BM;Fujita PA;Diekhans M;Cline MS;Clawson H;Barber GP;Haussler D;James Kent W
通讯作者: James Kent W
DOI: 10.4161/rna.4.2.4640
发表时间: 2007-04-01
期刊: RNA BIOLOGY
影响因子: 4.1
作者:
Beitzinger, Michaela;Peters, Lasse;Meister, Gunter
通讯作者: Meister, Gunter
DOI: 10.1261/rna.563707
发表时间: 2007-08-01
期刊: RNA
影响因子: 4.5
作者:
Easow, George;Teleman, Aurelio A.;Cohen, Stephen M.
通讯作者: Cohen, Stephen M.