Uptake of metal cations by fibroblasts in vitro.
Uptake of metal cations by fibroblasts in vitro.
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体外成纤维细胞对金属阳离子的摄取。
DOI：
10.1002/jbm.820270212
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Craig,RG
中科院分区：
文献类型：
--
作者：
Wataha,JC;Hanks,CT;Craig,RG
使用原子吸收光谱法评估Balb/c 3 T3成纤维细胞体外培养物对Ag+1、Au+4、Cd+2、Cu+2、In+3、Ni+2、Pd+2和Zn+2的吸收，其为细胞培养基中阳离子浓度的函数。还测量了这种吸收的可逆性。金属阳离子在细胞中积累的趋势有400倍的差异; In+3积累最多，而Pd+2积累最少。在细胞中的阳离子的摄取与所有的阳离子在其50%的毒性浓度的培养基中的阳离子的浓度线性增加。这种吸收的抑制比三种阳离子的初始吸收慢，更详细地研究（Cd+2，In+3，和Ni+2）。初始暴露的持续时间影响的比例的金属阳离子被保留的细胞5小时后，阳离子从介质中除去。当初始暴露时间从2 h增加到6 h时，Cd+2的滞留比例没有变化，而In+3的滞留比例下降，Ni+2的滞留比例上升。细胞积聚这些阳离子的趋势与其细胞毒性效力（先前测量）相关。John Wiley & Sons，Inc.
Atomic absorption spectroscopy was used to assess uptake of Ag+1, Au+4, Cd+2, Cu+2, In+3, Ni+2, Pd+2, and Zn+2byin vitrocultures of Balb/c 3T3 fibroblasts as a function of concentration of the cations in cell‐culture medium. Reversibility of this uptake was also measured. Metal cations exhibited a 400‐fold difference in their tendency to accumulate in the cells; In+3tended to accumulate the most, whereas Pd+2accumulated the least. Uptake of the cations in the cells increased linearly with the concentration of the cation in the medium for all cations up to their 50% toxicity concentrations. Reversal of this uptake was slower than that of the initial uptake for three cations studied in more detail (Cd+2, In+3, and Ni+2). The duration of the initial exposure affected the proportion of the metal cations that were retained by the cells 5 h after the cations were removed from the medium. The proportion of retained Cd+2did not change when the initial exposure was increased from 2 h to 6 h, whereas the proportion of retained In+3decreased and Ni+2increased over the same period. The tendency of the cells to accumulate these cations correlated with their cytotoxic potency (measured previously). © 1993 John Wiley & Sons, Inc.
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DOI：
10.1016/b978-0-12-364931-7.50007-0
发表时间：
1990
期刊：
International review of experimental pathology
影响因子：
--
作者：
D. R. Winge;Rajesh K. Mehra
通讯作者：
D. R. Winge;Rajesh K. Mehra
腐蚀离子与人类唾液的结合。
影响因子：
14
作者：
Mueller,HJ
通讯作者：
Mueller,HJ
金属阳离子对真核细胞代谢的体外影响。
DOI：
10.1002/jbm.820250907
发表时间：
1991
期刊：
Journal of biomedical materials research
影响因子：
--
作者：
Wataha,JC;Hanks,CT;Craig,RG
通讯作者：
Craig,RG
用各种铂配位化合物处理的中国仓鼠卵巢细胞中 DNA 交联的诱导和修复与铂与 DNA 的结合、细胞毒性、致突变性和抗肿瘤活性有关。
影响因子：
11.2
作者：
A. C. Plooy;M. Dijk;P. Lohman
通讯作者：
P. Lohman