Evolution of Recombination Due to Random Drift
Evolution of Recombination Due to Random Drift
复制标题
由于随机漂移导致的重组演化
作者：
N. Barton;S. Otto
在有限的选择群体中，遗传漂变平均产生负连锁不平衡，即使选择独立作用（即，在所有的位置上。负不均衡减少了适应度的方差，因此，根据费舍尔（1930）的基本定理，减缓了平均适应度的增长速度。增加重组的修饰语消除了阻碍选择的负不平衡，从而通过“搭便车”增加了频率。因此，在有限的群体中，连锁不平衡的随机波动有利于重组率增加的演变，即使在基因座之间没有上位相互作用，甚至当不平衡最初是不存在的。在这篇文章中开发的方法使我们能够量化选择的强度作用于修饰等位基因，增加重组在有限的人口。分析表明，随机产生的连锁不平衡选择增加重组，结果证实了蒙特卡洛模拟。当基因座间的连锁紧密、有益等位基因的频率从低到高、种群规模较小时，选择增加重组的修饰基因的频率最高。
In finite populations subject to selection, genetic drift generates negative linkage disequilibrium, on average, even if selection acts independently (i.e., multiplicatively) upon all loci. Negative disequilibrium reduces the variance in fitness and hence, by Fisher's (1930) fundamental theorem, slows the rate of increase in mean fitness. Modifiers that increase recombination eliminate the negative disequilibria that impede selection and consequently increase in frequency by “hitchhiking.” Thus, stochastic fluctuations in linkage disequilibrium in finite populations favor the evolution of increased rates of recombination, even in the absence of epistatic interactions among loci and even when disequilibrium is initially absent. The method developed within this article allows us to quantify the strength of selection acting on a modifier allele that increases recombination in a finite population. The analysis indicates that stochastically generated linkage disequilibria do select for increased recombination, a result that is confirmed by Monte Carlo simulations. Selection for a modifier that increases recombination is highest when linkage among loci is tight, when beneficial alleles rise from low to high frequency, and when the population size is small.
影响因子：
3.1
作者：
KONDRASHOV, AS
通讯作者：
KONDRASHOV, AS
影响因子：
3.3
作者：
Lee Altenberg;Marcus W. Feldman
通讯作者：
Lee Altenberg;Marcus W. Feldman