Critical role of the ventral temporal lobe in naming.
Critical role of the ventral temporal lobe in naming.
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作者：
词汇提取缺陷是多种不同神经系统疾病的特征。然而，对此负责的确切底物尚不清楚。我们研究了一个大型队列的患者接受手术的优势颞叶的药物难治性癫痫（n = 95），以本地化的大脑区域，与失名症。我们进行了一个多变量的基于体素的病变症状映射分析，相关的手术病变在颞叶命名能力的变化。此外，我们使用了基于表面的混合效应多水平分析，以估计组水平的宽带γ活动在命名与皮层电图记录的患者的一个子集，并整合这些结果与病变缺陷的结果。我们观察到，腹侧颞区，中间梭状回为中心，显着与命名下降。此外，我们发现颞叶切除术的腹侧与命名能力的下降呈线性相关，一旦切除从腹侧颞叶前端延伸6 cm，就会出现临床显著下降。在皮层电图上，这些皮层区域中的大多数在视觉处理后功能活跃。这些位点与平面回波成像中的敏感性伪影部位一致，这可以解释为什么该区域以前被低估为术后命名缺陷的位点。总之，这些数据突出了腹侧颞叶皮层在命名中的重要贡献及其在颞叶切除术后命名障碍的病理生理学中的重要作用。因此，手术策略应尝试保留该区域，以减轻术后语言障碍。
Lexical retrieval deficits are characteristic of a variety of different neurological disorders. However, the exact substrates responsible for this are not known. We studied a large cohort of patients undergoing surgery in the dominant temporal lobe for medically intractable epilepsy (n = 95) to localize brain regions that were associated with anomia. We performed a multivariate voxel-based lesion–symptom mapping analysis to correlate surgical lesions within the temporal lobe with changes in naming ability. Additionally, we used a surface-based mixed-effects multilevel analysis to estimate group-level broadband gamma activity during naming across a subset of patients with electrocorticographic recordings and integrated these results with lesion–deficit findings. We observed that ventral temporal regions, centered around the middle fusiform gyrus, were significantly associated with a decline in naming. Furthermore, we found that the ventral aspect of temporal lobectomies was linearly correlated to a decline in naming, with a clinically significant decline occurring once the resection extended 6 cm from the anterior tip of the temporal lobe on the ventral surface. On electrocorticography, the majority of these cortical regions were functionally active following visual processing. These loci coincide with the sites of susceptibility artifacts during echoplanar imaging, which may explain why this region has been previously underappreciated as the locus responsible for postoperative naming deficits. Taken together, these data highlight the crucial contribution of the ventral temporal cortex in naming and its important role in the pathophysiology of anomia following temporal lobe resections. As such, surgical strategies should attempt to preserve this region to mitigate postoperative language deficits.
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影响因子：
5.6
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Drane DL;Loring DW;Voets NL;Price M;Ojemann JG;Willie JT;Saindane AM;Phatak V;Ivanisevic M;Millis S;Helmers SL;Miller JW;Meador KJ;Gross RE
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