Glucagon Test Is a Useful Predictor of Withdrawal From Insulin Therapy in Subjects With Type 2 Diabetes Mellitus.
Glucagon Test Is a Useful Predictor of Withdrawal From Insulin Therapy in Subjects With Type 2 Diabetes Mellitus.
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DOI：
10.3389/fendo.2022.871660
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发表时间：
2022
影响因子：
5.2
通讯作者：
Kaneto, Hideaki
中科院分区：
文献类型：
--
作者：
Iwamoto, Yuichiro;Kimura, Tomohiko;Tatsumi, Fuminori;Sugisaki, Toshitomo;Kubo, Masato;Nakao, Erina;Dan, Kazunori;Wamata, Ryo;Iwamoto, Hideyuki;Takahashi, Kaio;Sanada, Junpei;Fushimi, Yoshiro;Katakura, Yukino;Shimoda, Masashi;Nakanishi, Shuhei;Mune, Tomoatsu;Kaku, Kohei;Kaneto, Hideaki
关键词：
评估内源性胰岛素分泌能力的试验有很多。然而，在临床实践中详细检验哪种方法最准确地反映内源性胰岛素分泌能力的研究，特别是在高血糖状态下，只有有限数量的研究。这项研究的目的是寻找内源性胰岛素分泌能力和因高血糖而需要住院的2型糖尿病患者胰岛素撤退的可能预测因素。在住院期间内源性胰岛素分泌试验中，停用胰岛素组的心肺复苏、心肺复苏指数和胰升糖素负荷后的Δ心肺复苏均显著高于对照组。空腹心肺复苏指数、HOMA-β、Suit、24小时尿心肺复苏排泄量两组间差异无统计学意义。在胰岛素戒断组的胰升糖素试验中，Δ心肺复苏的临界值为1 0 ng/m L，Δ心肺复苏大于或等于1 ng/m L的戒断率为6 9.2%，<1 ng/m L的戒断率为2 5.0%。总之，在因高血糖而需要住院的2型糖尿病患者中，胰高血糖素试验可能是预测胰岛素停用的可能性以及评估内源性胰岛素分泌能力的最有力的工具。
There are many tests for evaluating endogenous insulin secretory capacity. However, there are only a limited number of studies that have examined in detail in clinical practice which method most accurately reflects the ability to secrete endogenous insulin especially in hyperglycemic state. The purpose of this study was to find the endogenous insulin secretory capacity and a possible predictor of insulin withdrawal in subjects with type 2 diabetes requiring hospitalization due to hyperglycemia. In the endogenous insulin secretory test during hospitalization, CPR, CPR index, and ΔCPR after glucagon loading were all significantly higher in the insulin withdrawal group. On the other hand, there were no difference in fasting CPR index, HOMA-β, SUIT, and 24-hour urinary CPR excretion between the two groups. In the glucagon test of the insulin withdrawal group, the cutoff value of ΔCPR was 1.0 ng/mL, the withdrawal rate of ΔCPR of 1.0 ng/mL or more was 69.2%, and the withdrawal rate of less than 1.0 ng/mL was 25.0%. In conclusion, it is likely that glucagon test is the most powerful tool for predicting the possibility of insulin withdrawal as well as for evaluating endogenous insulin secretory capacity in subjects with type 2 diabetes requiring hospitalization due to hyperglycemia.
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影响因子：
158.5
作者：
Holman, Rury R.;Paul, Sanjoy K.;Neil, H. Andrew W.
通讯作者：
Neil, H. Andrew W.
影响因子：
5.1
作者：
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影响因子：
8.2
作者：
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通讯作者：
TURNER, RC
影响因子：
168.9
作者：
Turner, RC;Holman, RR;Hadden, D
通讯作者：
Hadden, D
影响因子：
16.2
作者：
MATSUDA, A;KUZUYA, T
通讯作者：
KUZUYA, T