A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States.
A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States.
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DOI:
10.1186/s13756-018-0346-9
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发表时间:
2018
影响因子:
5.5
通讯作者:
Perencevich EN
中科院分区:
文献类型:
--
作者:
Livorsi DJ;Chorazy ML;Schweizer ML;Balkenende EC;Blevins AE;Nair R;Samore MH;Nelson RE;Khader K;Perencevich EN
Carbapenem-resistant Enterobacteriaceae (CRE) pose an urgent public health threat in the United States. An important step in planning and monitoring a national response to CRE is understanding its epidemiology and associated outcomes. We conducted a systematic literature review of studies that investigated incidence and outcomes of CRE infection in the US. We performed searches in MEDLINE via Ovid, CDSR, DARE, CENTRAL, NHS EED, Scopus, and Web of Science for articles published from 1/1/2000 to 2/1/2016 about the incidence and outcomes of CRE at US sites. Five studies evaluated incidence, but many used differing definitions for cases. Across the entire US population, the reported incidence of CRE was 0.3–2.93 infections per 100,000 person-years. Infection rates were highest in long-term acute-care (LTAC) hospitals. There was insufficient data to assess trends in infection rates over time. Four studies evaluated outcomes. Mortality was higher in CRE patients in some but not all studies. While the incidence of CRE infections in the United States remains low on a national level, the incidence is highest in LTACs. Studies assessing outcomes in CRE-infected patients are limited in number, small in size, and have reached conflicting results. Future research should measure a variety of clinical outcomes and adequately adjust for confounders to better assess the full burden of CRE. The online version of this article (10.1186/s13756-018-0346-9) contains supplementary material, which is available to authorized users.
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DOI:
10.1136/bmj.b2535
发表时间:
2009-07-21
期刊:
BMJ (Clinical research ed.)
影响因子:
--
作者:
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者:
PRISMA Group
DOI:
10.1093/cid/ciw461
发表时间:
2016-10-01
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
作者:
Ray MJ;Lin MY;Weinstein RA;Trick WE
通讯作者:
Trick WE
影响因子:
4.9
作者:
Gohil, Shruti K.;Singh, Raveena;Huang, Susan S.
通讯作者:
Huang, Susan S.
影响因子:
120.7
作者:
Epstein, Lauren;Hunter, Jennifer C.;Kallen, Alexander J.
通讯作者:
Kallen, Alexander J.
影响因子:
4.5
作者:
Brennan, Brenda M.;Coyle, Joseph R.;Kaye, Keith S.
通讯作者:
Kaye, Keith S.