Viscosity of mixtures of sickle and normal red cells at varying hematocrit levels
Viscosity of mixtures of sickle and normal red cells at varying hematocrit levels
复制标题
不同血细胞比容水平下镰状红细胞和正常红细胞混合物的粘度
作者：
E. Schmalzer;J. O. Lee;A. Brown;S. Usami;S. Chien
血液悬浮液中的粘度（η）受总血细胞比容（HT）以及细胞的变形能力的影响。这些综合因素对镰状细胞悬液流变学行为和输血指南的影响尚未充分探讨。因此，在旋转粘度计中测定洗涤的正常（AA）和镰状（SS）红细胞的混合物的η作为SS细胞的血细胞比容水平（HS）、HT、氧张力（PO2）和剪切速率的函数。HT：eta比值可作为潜在氧输送的指标。最佳HT（最大HT：eta）随着HS或HS：HT比的降低而逐渐升高：在给定的HT下，HT：eta随着HS的降低而升高，特别是在低HS值下。这些数据支持这样的概念，即单纯输血对患者的益处不如换血，通过使患者达到非常低的HS水平可以获得实质性益处。当HS：HT比而不是HS保持恒定时，eta随HT更急剧上升的发现表明，HS的绝对水平可能比HS：HT比更有用，可作为输血方案的指导。
Viscosity (eta) in a blood suspension is affected by the total hematocrit (HT) as well as by the deformability of the cells. The impact of these combined factors on the rheologic behavior of sickle cell suspensions and on guidelines for transfusion has not been explored fully. Therefore, the eta of mixtures of washed normal (AA) and sickle (SS) red cells was determined in a rotational viscosimeter as a function of the hematocrit level of SS cells (HS), HT, oxygen tension (PO2), and shear rate. The ratio HT:eta can be taken as an index of potential oxygen delivery. The optimal HT (for maximum HT:eta) became progressively higher as the HS or the HS:HT ratio was lowered: at a given HT, HT:eta rose with a decrease in HS, especially at low HS values. These data support the concept that simple transfusion alone is not as beneficial to the patient as exchange transfusion and that substantial benefit can be obtained by bringing the patient to very low HS levels. The finding that eta rose with HT more steeply when the HS:HT ratio rather than HS was held constant suggested that the absolute level of HS may be more useful than the HS:HT ratio as a guide for a transfusion regimen.
影响因子：
3.1
作者：
Vayo,MM;Lipowsky,HH;Karp,N;Schmalzer,E;Chein,S
通讯作者：
Chein,S
镰状细胞性贫血的神经系统并发症。
DOI：
10.1097/00043426-198224000-00006
发表时间：
1982
期刊：
The American journal of pediatric hematology/oncology
影响因子：
--
作者：
Sarnaik,SA;Lusher,JM
通讯作者：
Lusher,JM