The diagnosis and treatment of pseudoprogression, radiation necrosis and brain tumor recurrence.
The diagnosis and treatment of pseudoprogression, radiation necrosis and brain tumor recurrence.
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DOI：
10.3390/ijms150711832
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发表时间：
2014-07-03
影响因子：
5.6
通讯作者：
Zadeh G
中科院分区：
文献类型：
--
作者：
Parvez K;Parvez A;Zadeh G
放射治疗是治疗脑转移瘤和恶性胶质瘤的重要手段。治疗后监测通常涉及连续磁共振成像。临床医生面临的一个挑战是在诊断和管理的可疑钆增强病变发现的成像。可疑病变可能代表治疗后放射效应（PTRE），如假进展、放射性坏死或肿瘤复发。在诊断成像模式方面已经取得了重大进展，以帮助区分这些实体。手术和医疗干预也被开发来治疗PTRE。在这篇综述中，我们讨论了病理生理学，临床表现，诊断成像模式，并提供了一个算法的管理假性进展，放射性坏死和肿瘤复发。
Radiation therapy is an important modality used in the treatment of patients with brain metastatic disease and malignant gliomas. Post-treatment surveillance often involves serial magnetic resonance imaging. A challenge faced by clinicians is in the diagnosis and management of a suspicious gadolinium-enhancing lesion found on imaging. The suspicious lesion may represent post-treatment radiation effects (PTRE) such as pseudoprogression, radiation necrosis or tumor recurrence. Significant progress has been made in diagnostic imaging modalities to assist in differentiating these entities. Surgical and medical interventions have also been developed to treat PTRE. In this review, we discuss the pathophysiology, clinical presentation, diagnostic imaging modalities and provide an algorithm for the management of pseudoprogression, radiation necrosis and tumor recurrence.
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DOI：
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发表时间：
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