Meiosis I: when chromosomes undergo extreme makeover.

Meiosis I: when chromosomes undergo extreme makeover.
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DOI:
10.1016/j.ceb.2013.07.009
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发表时间:
2013-12
影响因子:
7.5
通讯作者:
Uenal, Elcin
Uenal, Elcin
中科院分区:
生物学2区
文献类型:
--
作者:
Miller, Matthew P.;Amon, Angelika;Uenal, Elcin

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The ultimate success of cell division relies on the accurate partitioning of the genetic material. Errors in this process occur in nearly all tumors and are the leading cause of miscarriages and congenital birth defects in humans. Two cell divisions, mitosis and meiosis, use common as well as unique mechanisms to ensure faithful chromosome segregation. In mitosis, alternating rounds of DNA replication and chromosome segregation preserves the chromosome complement of the progenitor cell. In contrast, during meiosis two consecutive rounds of nuclear division, meiosis I and meiosis II, follow a single round of DNA replication to reduce the chromosome complement by half. Meiosis likely evolved through changes to the mitotic cell division program. This review will focus on the recent findings describing the modifications that transform mitosis into meiosis.
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