Abnormal activity-dependent brain lactate and glutamate+glutamine responses in panic disorder.
Abnormal activity-dependent brain lactate and glutamate+glutamine responses in panic disorder.
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DOI：
10.1016/j.biopsych.2012.12.015
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发表时间：
2013-06-01
影响因子：
10.6
通讯作者：
Unruh, April M.
中科院分区：
文献类型：
--
作者：
Maddock, Richard J.;Buonocore, Michael H.;Miller, Amber R.;Yoon, Jong H.;Soosman, Steffan K.;Unruh, April M.
关键词：
先前的证据表明惊恐障碍（PD）的特征是神经代谢异常，包括对神经激活的脑乳酸反应增加。乳酸盐反应增加可能反映了对神经激活的代谢反应的普遍上调。然而，以前的研究在PD没有测量活动依赖性的变化，脑代谢物以外的乳酸。在这里，我们研究活动依赖性的变化，乳酸和谷氨酸加谷氨酰胺（glx）在PD。研究了21例PD患者（13例缓解，8例症状性）和12例健康志愿者。一个单一的体素，J-差异，磁共振波谱编辑序列被用来测量乳酸和glx的变化，视觉刺激引起的视觉皮层。PD患者的脑乳酸盐水平显著高于健康志愿者的活动依赖性增加。缓解和症状性PD患者的差异均具有显著性，彼此之间没有差异。PD患者glx的活动依赖性变化显著小于健康志愿者。对照组中乳酸和葡萄糖变化之间的时间相关性显著强于PD患者。新的证据表明，glx反应减少，并在时间上解耦的乳酸反应在PD中的活动依赖性脑代谢反应的一般上调的模型相矛盾。活动依赖性脑乳酸积累的增加似乎是PD的一个特征。鉴于乳酸和pH值在大脑中的密切关系，研究结果与大脑代谢和pH值失调的模型相一致，该模型与酸敏感性恐惧回路的功能改变相关，从而导致PD的特质脆弱性。
Prior evidence suggests panic disorder (PD) is characterized by neurometabolic abnormalities, including increased brain lactate responses to neural activation. Increased lactate responses could reflect a general upregulation of metabolic responses to neural activation. However, prior studies in PD have not measured activity-dependent changes in brain metabolites other than lactate. Here we examine activity-dependent changes in both lactate and glutamate plus glutamine (glx) in PD. Twenty-one PD patients (13 remitted, 8 symptomatic) and 12 healthy volunteers were studied. A single-voxel, J-difference, magnetic resonance spectroscopy editing sequence was used to measure lactate and glx changes in visual cortex induced by visual stimulation. PD patients had significantly greater activity-dependent increases in brain lactate than healthy volunteers. The differences were significant for both remitted and symptomatic PD patients, who did not differ from each other. Activity-dependent changes in glx were significantly smaller in PD patients than in healthy volunteers. The temporal correlation between lactate and glx changes was significantly stronger in control subjects than in PD patients. The novel demonstration that glx responses are diminished and temporally decoupled from lactate responses in PD contradicts the model of a general upregulation of activity-dependent brain metabolic responses in PD. The increase in activity-dependent brain lactate accumulation appears to be a trait feature of PD. Given the close relationship between lactate and pH in the brain, the findings are consistent with a model of brain metabolic and pH dysregulation associated with altered function of acid-sensitive fear circuits contributing to trait vulnerability in PD.
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DOI：
10.1523/jneurosci.0360-09.2009
发表时间：
2009-04-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Coryell MW;Wunsch AM;Haenfler JM;Allen JE;Schnizler M;Ziemann AE;Cook MN;Dunning JP;Price MP;Rainier JD;Liu Z;Light AR;Langbehn DR;Wemmie JA
通讯作者：
Wemmie JA
DOI：
10.1097/00004850-199506000-00003
发表时间：
1995-06-01
影响因子：
2.6
作者：
BANDELOW, B
通讯作者：
BANDELOW, B
影响因子：
11.9
作者：
Fujiwara, Akiko;Yoshida, Takeshi;Hirayasu, Yoshio
通讯作者：
Hirayasu, Yoshio
影响因子：
3.7
作者：
Chechko N;Wehrle R;Erhardt A;Holsboer F;Czisch M;Sämann PG
通讯作者：
Sämann PG
影响因子：
10.6
作者：
Coryell, Matthew W.;Ziemann, Adam E.;Wemmie, John A.
通讯作者：
Wemmie, John A.