Wnt5a expression and prognosis in stage II-III colon cancer.
Wnt5a expression and prognosis in stage II-III colon cancer.
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DOI：
10.1016/j.tranon.2020.100892
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发表时间：
2021-01
影响因子：
5
通讯作者：
Riis LB
中科院分区：
文献类型：
--
作者：
Lund CM;Dyhl-Polk A;Nielsen DL;Riis LB
癌症转移是大多数癌症死亡的原因。分泌糖蛋白Wnt 5a损害肿瘤细胞迁移并降低侵袭和转移。肿瘤细胞中Wnt 5a的高表达与乳腺癌、前列腺癌和上皮性卵巢癌患者的良好预后相关。我们的目的是研究Wnt 5a表达与II/III期结肠癌（CC）患者预后之间的关系。我们进行了一项回顾性单中心研究，评估了345例II/III期原发性CC根治性切除术患者，这些患者在2001年至2015年期间开始了6个月的5-FU或卡培他滨±奥沙利铂辅助化疗。使用免疫组织化学用Wnt 5a抗体对来自切除标本的存档的福尔马林固定的石蜡包埋的肿瘤组织进行染色。根据染色细胞的强度和百分比评估细胞质Wnt 5a染色。根据高（n = 230）或低（n = 115）Wnt 5a表达将患者分组。采用Kaplan-Meier曲线和Long rank检验分析两组的无病生存期（DFS）和总生存期（OS）。Wnt 5a阴性肿瘤患者的体能状态（PS）显著低于Wnt 5a高表达患者（p = 0.046）。在5年DFS（p = 0.517）或5年OS（p = 0.415）方面，Wnt 5a低表达和高表达患者之间无显著差异。PS差与较低的DFS（p = 0.002）和OS（p < 0.001）相关。总之，我们发现II/III期CC患者的预后没有显著差异，这取决于他们的Wnt 5a表达。Wnt 5a阴性肿瘤患者的PS显著低于高水平患者。差的PS与较低的DFS和OS相关。肿瘤细胞中Wnt 5a的高表达与患有不同癌症的患者的显著更好的结果相关。我们发现II-III期结肠癌患者的生存率没有差异，这取决于他们的Wnt 5a表达。Wnt 5a低表达的患者的体能状态比高表达的患者明显差。表现状态不佳预示预后较差。
Cancer metastases accounts for most cancer deaths. The secreting glycoprotein Wnt5a impairs tumor cell migration and reduces invasiveness and metastasis. High Wnt5a expression in tumor cells is correlated to better outcomes in patients with breast, prostate and epithelial ovarian cancer. We aimed to investigate the association between the Wnt5a expression and outcomes in patients with colon cancer (CC) stage II/III. We performed a retrospective single-center study evaluating 345 patients with radical resection for primary CC, stage II/III, who started 6 months of adjuvant chemotherapy with 5-FU or capecitabine ± oxaliplatin between 2001 and 2015. Archived formalin-fixed paraffin embedded tumor tissue from resection specimens were stained with Wnt5a antibody using immunohistochemistry. Cytoplasmatic Wnt5a staining was assessed according to intensity and percentage of stained cells. Patients were divided in groups depending on high (n = 230) or low (n = 115) Wnt5a expression. Disease free survival (DFS) and overall survival (OS) were analyzed for the two groups using Kaplan-Meier plots and Long rank test. Patients with Wnt5a-negative tumors had significantly poorer performance status (PS) than patients with high Wnt5a expression (p = 0.046). No significant difference was seen between patients with low and high Wnt5a expression in terms of 5-year DFS (p = 0.517) or 5-year OS (p = 0.415). Poor PS was associated with lower DFS (p = 0.002) and OS (p < 0.001). In conclusion, we found no significant difference in prognosis for patients with stage II/III CC depending on their Wnt5a expression. Patients with Wnt5a-negative tumors had significant poorer PS than patients with higher levels. Poor PS was associated with lower DFS and OS. High expression of Wnt5a in tumor cells are correlated to significantly better outcomes in patients with different cancers. We found no difference in survival among patients with colon cancer stage II-III depending on their Wnt5a expression. Patients with low Wnt5a expression had significantly poor performance status than patients with high levels. Poor performance status was shown to predict poorer outcomes.
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