Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues.
Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues.
复制标题
DOI：
10.1155/2014/103923
复制
发表时间：
2014
影响因子：
--
通讯作者：
Turley EA
中科院分区：
文献类型：
--
作者：
Tolg C;McCarthy JB;Yazdani A;Turley EA
肿瘤和伤口具有许多相似性，包括组织结构、细胞极性和细胞分化的丧失、异常的细胞外基质（ECM）重塑（Ballard等人，2006）增加的炎症、血管生成和升高的细胞迁移和增殖。尽管这些变化在修复伤口时是短暂的，但肿瘤不会恢复组织结构，而是通过正常组织结构的丧失部分地促进其持续进展。因此，肿瘤通常被描述为无法愈合的伤口。ECM组分透明质酸（HA）及其受体RHAMM都与伤口修复和肿瘤进展有关。这篇综述强调了它们在这些过程中作用的相似性和差异，并提出RHAMM调节的伤口修复功能可能有助于肿瘤微环境的“癌变”。
Tumors and wounds share many similarities including loss of tissue architecture, cell polarity and cell differentiation, aberrant extracellular matrix (ECM) remodeling (Ballard et al., 2006) increased inflammation, angiogenesis, and elevated cell migration and proliferation. Whereas these changes are transient in repairing wounds, tumors do not regain tissue architecture but rather their continued progression is fueled in part by loss of normal tissue structure. As a result tumors are often described as wounds that do not heal. The ECM component hyaluronan (HA) and its receptor RHAMM have both been implicated in wound repair and tumor progression. This review highlights the similarities and differences in their roles during these processes and proposes that RHAMM-regulated wound repair functions may contribute to “cancerization” of the tumor microenvironment.
登录
查看更多内容
影响因子：
2.9
作者：
David-Raoudi, Maha;Tranchepain, Frederic;Pujol, Jean-Pierre
通讯作者：
Pujol, Jean-Pierre
影响因子：
6
作者：
de la Motte, Carol;Nigro, Julie;Stern, Robert
通讯作者：
Stern, Robert
影响因子：
3.6
作者：
Caskey, Robert C.;Allukian, Myron;Liechty, Kenneth W.
通讯作者：
Liechty, Kenneth W.
影响因子：
6.4
作者：
Auvinen, Paivi;Tammi, Raija;Tammi, Markku
通讯作者：
Tammi, Markku
影响因子：
4.8
作者：
Amara, FM;Entwistle, J;Wright, JA
通讯作者：
Wright, JA