Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis.
Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis.
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DOI：
10.1111/j.1600-0757.2009.00333.x
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发表时间：
2010-10
影响因子：
18.6
通讯作者：
Darveau RP
中科院分区：
文献类型：
--
作者：
Jain S;Darveau RP
脂多糖是构成革兰氏阴性细菌外表面的一种重要大分子。脂多糖被人类宿主识别为外来分子，激发旨在消除细菌入侵者的免疫应答。来自大肠杆菌等肠道细菌的脂多糖引起强烈的免疫反应。在分子水平上，这是因为E。大肠杆菌脂A是脂多糖的生物活性成分，是天然免疫受体Toll样受体4（TLR 4）的强激动剂。然而，来自牙周病病原体牙龈卟啉单胞菌的脂多糖激发了非常弱的免疫应答。此外，牙龈卟啉单胞菌能够合成脂质A分子的异质群体，其在结构上彼此细微不同。这些脂质A结构之一具有抑制由脂质A激动剂在TLR 4处引起的免疫应答的能力。牙龈卟啉单胞菌的弱激动性和拮抗性脂质A结构被认为在破坏维持口腔健康所需的口腔免疫稳态中起重要作用，从而促进牙周病。
Lipopolysaccharide is an essential macromolecule that comprises the outer surface of gramnegative bacteria. Lipopolysaccharide, recognized by the human host as a foreign molecule, elicits an immune response that is designed to eliminate the bacterial intruder. Lipopolysaccharide from enteric bacteria such as Escherichia coli provokes a strong immune response. On the molecular level this is because E. coli lipid A, the bio-active component of lipopolysaccharide, is a strong agonist of the innate immune receptor, Tolllike receptor 4 (TLR4). However, lipopolysaccharide from the periodontopathogen, Porphyromonas gingivalis, elicits a strikingly weak immune response. Additionally, P. gingivalis is capable of synthesizing a heterogeneous population of lipid A molecules, which are subtly different from each other in structure. One of these lipid A structures has the capacity to dampen the immune response elicited by lipid A agonists at TLR4. The weak agonistic and antagonistic lipid A structures of P. gingivalis are proposed to play an important role in disrupting the oral immune homeostasis required for maintaining oral health, and thereby promote periodontal disease.
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影响因子：
3.4
作者：
Coats SR;Jones JW;Do CT;Braham PH;Bainbridge BW;To TT;Goodlett DR;Ernst RK;Darveau RP
通讯作者：
Darveau RP
影响因子：
3.1
作者：
Baker, PJ;Dixon, M;Roopenian, DC
通讯作者：
Roopenian, DC
影响因子：
3.1
作者：
Al-Qutub, Montaser N.;Braham, Pamela H.;Darveau, Richard P.
通讯作者：
Darveau, Richard P.
影响因子：
3.1
作者：
DARVEAU, RP;CHARNETZKY, WT;HANCOCK, REW
通讯作者：
HANCOCK, REW
影响因子：
3.2
作者：
Bainbridge, Brian W.;Karimi-Naser, Lisa;Darveau, Richard P.
通讯作者：
Darveau, Richard P.