Joint effect of insulin signaling genes on all-cause mortality.
Joint effect of insulin signaling genes on all-cause mortality.
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DOI：
10.1016/j.atherosclerosis.2014.10.005
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发表时间：
2014-12
期刊：
影响因子：
5.3
通讯作者：
Trischitta, Vincenzo
中科院分区：
文献类型：
--
作者：
Menzaghi, Claudia;Fontana, Andrea;Copetti, Massimiliano;Rizza, Stefano;Spoto, Belinda;Buranasupkajorn, Patinut;Tripepi, Giovanni;Marucci, Antonella;Bailetti, Diego;Hastings, Timothy;Testa, Alessandra;Mendonca, Christine;Mallamaci, Francesca;De Cosmo, Salvatore;Bacci, Simonetta;Federici, Massimo;Doria, Alessandro;Zoccali, Carmine;Trischitta, Vincenzo
We have previously reported the combined effect of SNPs perturbing insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on insulin resistance (IR), type 2 diabetes (T2D) and cardiovascular events. We here investigated whether such a combined effect affects also all-cause mortality in a sample of 1,851 Whites of European ancestry. We investigated a first sample of 721 patients, 232 deaths, 3,389 person-years (py). Replication was assessed in two samples of patients with T2D: the Gargano Mortality Study (GMS) of 714 patients, 127 deaths, 5,426 py and the Joslin Kidney Study (JKS) comprising 416 patients, 214 deaths, 5,325 py. In the first sample, individuals carrying 1 or ≥ 2 risk alleles had 33% (p=0.06) and 51% (p=0.02) increased risk of mortality, as compared with individuals with no risk alleles. A similar, though not significant, trend was obtained in the two replication samples only for subject carrying ≥ 2 risk alleles. In a pooled analysis, individuals carrying ≥ 2 risk alleles had higher mortality rate as compared to those carrying 0 risk alleles (HR=1.34, 95%CI=1.08–1.67; p=0.008), and as compared to those carrying only one risk allele (HR=1.41, 95%CI=1.13–1.75; p=0.002). This association was independent from several possible confounders including sex, age, BMI, hypertension and diabetes status. Our data suggest that variants affecting insulin signaling exert a joint effect on all-cause mortality and is consistent with a role of abnormal insulin signaling on mortality risk.
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影响因子：
5.3
作者：
Bacci S;Prudente S;Copetti M;Spoto B;Rizza S;Baratta R;Di Pietro N;Morini E;Di Paola R;Testa A;Mallamaci F;Tripepi G;Zhang YY;Mercuri L;Di Silvestre S;Lauro R;Malatino L;Consoli A;Pellegrini F;Pandolfi A;Frittitta L;Zoccali C;Federici M;Doria A;Trischitta V
通讯作者：
Trischitta V
影响因子：
3.7
作者：
Di Paola R;Caporarello N;Marucci A;Dimatteo C;Iadicicco C;Del Guerra S;Prudente S;Sudano D;Miele C;Parrino C;Piro S;Beguinot F;Marchetti P;Trischitta V;Frittitta L
通讯作者：
Frittitta L
影响因子：
5.8
作者：
Hribal, ML;Federici, M;Sesti, G
通讯作者：
Sesti, G
影响因子：
5.8
作者：
Prudente, Sabrina;Morini, Eleonora;Trischitta, Vincenzo
通讯作者：
Trischitta, Vincenzo
影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES