Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample.
Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample.
复制标题
DOI：
10.1016/j.appet.2011.05.325
复制
发表时间：
2011-10
期刊：
影响因子：
5.4
通讯作者：
Fuemmeler BF
中科院分区：
文献类型：
--
作者：
Agurs-Collins T;Fuemmeler BF
抑郁症和多巴胺相关基因的变异都与食物消耗独立相关。抑郁症状可能与遗传变异协同作用，影响食物摄入。我们在国家青少年健康纵向研究（Add Health）中研究了高抑郁症状与多巴胺转运蛋白（SLC 6A 3）、单胺氧化酶A（MAOA）、多巴胺受体D2（DRD 2）和多巴胺受体D4（DRD 4）的功能多态性之间的相互作用，这些多态性与高热量甜食、高热量非甜食和低热量食物的摄入有关。多元线性回归分析被用来研究基因和抑郁症状及其相互作用（基因型高抑郁症状）对食物类别的主要影响。应用错误发现率标准进行多重比较表明，具有高度抑郁症状的女性与SLC 6A 3基因之间存在统计学显著的相互作用，例如，具有SLC 6A 3 10/10等位基因的女性比具有SLC 6A 3任何9等位基因的抑郁症状高的女性报告摄入更多的高热量甜食（LS平均10/10等位基因= 2.5，SE = 0.13; LS平均任何9个等位基因= 1.8，SE = 0.13，p<0.05）。这些发现强调了抑郁症和食物摄入之间的关系可能会因遗传多态性而变化。需要进一步的研究来证实这些发现。
Depression and variation in dopamine related genes have both independently been associated with food consumption. Depressive symptoms could synergistically interact with genetic variation to influence food intake. We examined the interaction between high depressive symptoms and functional polymorphisms of dopamine transportor (SLC6A3), monoamine oxidase A (MAOA), dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) on intake of high-calorie sweet, high-calorie non-sweet, and low-calorie foods in the National Longitudinal Study of Adolescent Health (Add Health). Multivariate linear regression analyses were used to examine main effects of gene and depression symptoms and their interaction (genotype-by-high depression symptoms) on food categories. Applying a false discovery rate criterion for multiple comparisons indicated a statistically significant interaction for females with high depressive symptoms and the SLC6A3 gene, such that those with the SLC6A3 10/10 allele reported greater intake of high-calorie sweet foods than their counterparts high in depressive symptoms with the SLC6A3 any 9 allele (LS mean 10/10 allele = 2.5, SE = .13; LS mean any 9 allele = 1.8, SE = .13, p<.05). These findings highlight that the relationship between depression and food intake may vary as a function of genetic polymorphism. Further research is needed to confirm these findings.
登录
查看更多内容
影响因子：
--
作者：
Eny, Karen M.;Corey, Paul N.;El-Sohemy, Ahmed
通讯作者：
El-Sohemy, Ahmed
影响因子：
11
作者：
Ducci, F.;Newman, T. K.;Goldman, D.
通讯作者：
Goldman, D.
影响因子：
2.6
作者：
Anchordoquy, HC;McGeary, C;Smolen, A
通讯作者：
Smolen, A
影响因子：
17.7
作者：
Brunswick, DJ;Amsterdam, JD;Newberg, A
通讯作者：
Newberg, A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y