Systemic factors are involved in the pathogenesis of proteinuria-induced glomerulosclerosis in adriamycin nephrotic rats.
Systemic factors are involved in the pathogenesis of proteinuria-induced glomerulosclerosis in adriamycin nephrotic rats.
复制标题
全身因素参与阿霉素肾病大鼠蛋白尿诱导的肾小球硬化的发病机制。
DOI：
--
复制
发表时间：
1999
影响因子：
13.6
通讯作者：
D. Zeeuw
中科院分区：
文献类型：
--
作者：
E. D. Boer;G. Navis;A. Tiebosch;P. D. Jong;D. Zeeuw
本研究旨在分离全身性肾病和蛋白尿在阿霉素肾病局灶节段性肾小球硬化（FGS）发病机制中的各自作用。为此，本研究检测了两种不同品系大鼠双侧（BAP）和单侧（UAP）蛋白尿和FGS。UAP是通过在阿霉素注射期间暂时切断一条肾动脉来保护一只肾脏免受阿霉素的暴露而获得的。在牺牲时（第12周），FGS存在于BAP和UAP暴露的肾脏中，但不存在于未暴露的肾脏中。FGS与BAP和UAP患者每肾蛋白尿显著相关。值得注意的是，对于给定的每肾蛋白尿，BAP组的硬化症评分高于UAP组，反映在每肾每mg蛋白尿的FGS评分比值较高（Wistar: BAP组为0.09 +/- 0.01，UAP组为0.05 +/- 0.01%/mg蛋白/ d， P < 0.05； Lewis: BAP组为0.12 +/- 0.01，UAP组为0.07 +/- 0.01%/mg蛋白/ d， P < 0.05），表明蛋白尿的局部损害作用受到其他因素的影响。胆固醇与BAP和UAP患者总蛋白尿相关。FGS评分与胆固醇呈正相关。后一种相关性在BAP和UAP中相似，表明胆固醇比每肾蛋白尿更统一地预测FGS。这与菌株特异性因素无关。在多元线性回归分析中，胆固醇被证明是蛋白尿肾脏中FGS最一致的预测因子，其预测价值比每肾蛋白尿更强。结论是，尽管肾病的系统性后遗症不会引起非蛋白尿肾脏的肾损害，但它们改变了蛋白尿肾脏中蛋白尿诱导的FGS的严重程度。
This study aims to dissociate the respective roles of systemic nephrosis and of the intrarenal effects of proteinuria in the pathogenesis of focal segmental glomerulosclerosis (FGS) in adriamycin nephrosis. To this purpose, this study examined proteinuria and FGS in bilateral (BAP) and unilateral proteinuria (UAP) in two different rat strains. UAP was obtained by protecting one kidney from exposure to adriamycin by temporary clipping of one renal artery during adriamycin injection. At sacrifice (week 12), FGS was present in BAP and in exposed kidneys in UAP, but not in unexposed kidneys. FGS correlated significantly with proteinuria per kidney in BAP and UAP. Remarkably, for a given proteinuria per kidney, the sclerosis score was higher in BAP than in UAP, reflected by a higher ratio of FGS score per mg proteinuria per kidney (Wistar: 0.09 +/- 0.01 in BAP versus 0.05 +/- 0.01%/mg protein per d in UAP, P < 0.05; Lewis: 0.12 +/- 0.01 in BAP versus 0.07 +/- 0.01%/mg protein per d in UAP, P < 0.05), indicating that the local damaging effects of proteinuria are modified by other factors. Cholesterol correlated with total proteinuria in BAP and UAP. FGS score was positively correlated with cholesterol. The latter correlation was similar in BAP and UAP, indicating that cholesterol was a more uniform predictor for FGS than proteinuria per kidney. This was independent of strain-specific factors. On multilinear regression analysis, cholesterol turned out to be the most consistent predictor of FGS in proteinuric kidneys, with a stronger predictive value than proteinuria per kidney. It is concluded that although systemic sequelae of nephrosis do not induce renal damage in nonproteinuric kidneys, they modify the severity of proteinuria-induced FGS in proteinuric kidneys.
登录
查看更多内容
影响因子：
158.5
作者：
BRENNER, BM;MEYER, TW;HOSTETTER, TH
通讯作者：
HOSTETTER, TH
肾小球肥大和上皮细胞损伤调节大鼠进行性肾小球硬化。
DOI：
--
发表时间：
1989
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Fries,JW;Sandstrom,DJ;Meyer,TW;Rennke,HG
通讯作者：
Rennke,HG
影响因子：
15.9
作者：
FOGO, A;YOSHIDA, Y;ICHIKAWA, I
通讯作者：
ICHIKAWA, I
膳食胆固醇补充剂加剧慢性氨基核苷肾病。
影响因子：
19.6
作者：
Diamond,JR;Karnovsky,MJ
通讯作者：
Karnovsky,MJ