Five types of nonspiking interneurons in local pattern-generating circuits of the crayfish swimmeret system.

Five types of nonspiking interneurons in local pattern-generating circuits of the crayfish swimmeret system.
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小龙虾游泳足系统局部模式生成电路中的五种类型的非尖峰中间神经元。

DOI:
10.1152/jn.00079.2013
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发表时间:
2013
影响因子:
2.5
通讯作者:
Mulloney,Brian
Mulloney,Brian
中科院分区:
医学3区
文献类型:
--
作者:
Smarandache-Wellmann,Carmen;Weller,Cynthia;WrightJr,TerrenceM;Mulloney,Brian

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我们进行了定量分析的不同nonspiking interneurons的小龙虾swimmeret系统的本地模式生成电路。在每一个局部回路中,这些中间神经元控制着驱动游泳者运动的动力冲程和回程运动神经元的放电。这些中间神经元中有54个是在生理实验中用尖锐的微电极鉴定的,并填充了葡聚糖德克萨斯红、神经生物素或两者。五种类型的神经元的生理和解剖特征的组合的基础上确定。解剖学类别是基于从每个神经元获得的共聚焦图像堆栈测量的16个解剖学参数。结果支持两个功能类别的识别:抑制剂的动力冲程(IPS)和抑制剂的回程(IRS)。IPS类中间神经元有三种形态类型,具有相似的生理特性。IRS类有两种形态类型,其生理特性和解剖特征不同于IPS神经元,但在该类内相似。这五种类型中有三种以前没有被发现。回顾每种类型内的染料耦合的证据,我们得出结论,每种类型的IPS神经元和一种类型的IRS神经元作为单个副本出现在每个局部模式生成电路中。最后一种IRS类型包括可能在每个局部电路中作为染料耦合对出现的神经元。这些不同的interneurons在swimmeret图案生成电路的识别导致一个精致的模型的局部图案生成电路,包括突触连接,编码和解码所需的信息,为intersegmentation协调的swimmeret运动。
We conducted a quantitative analysis of the different nonspiking interneurons in the local pattern-generating circuits of the crayfish swimmeret system. Within each local circuit, these interneurons control the firing of the power-stroke and return-stroke motor neurons that drive swimmeret movements. Fifty-four of these interneurons were identified during physiological experiments with sharp microelectrodes and filled with dextran Texas red, Neurobiotin, or both. Five types of neurons were identified on the basis of combinations of physiological and anatomical characteristics. Anatomical categories were based on 16 anatomical parameters measured from stacks of confocal images obtained from each neuron. The results support the recognition of two functional classes: inhibitors of power stroke (IPS) and inhibitors of return stroke (IRS). The IPS class of interneuron has three morphological types with similar physiological properties. The IRS class has two morphological types with physiological properties and anatomical features different from the IPS neurons but similar within the class. Three of these five types have not been previously identified. Reviewing the evidence for dye coupling within each type, we conclude that each type of IPS neuron and one type of IRS neuron occur as a single copy in each local pattern-generating circuit. The last IRS type includes neurons that might occur as a dye-coupled pair in each local circuit. Recognition of these different interneurons in the swimmeret pattern-generating circuits leads to a refined model of the local pattern-generating circuit that includes synaptic connections that encode and decode information required for intersegmental coordination of swimmeret movements.
DOI: --
发表时间: 1985
期刊: The Journal of comparative neurology
影响因子: --
作者:
K. Skinner
通讯作者: K. Skinner
小龙虾游泳足系统中央模式发生器中的非尖峰相互作用和局部中间神经元
DOI: --
发表时间: 1980
期刊: Brain Research
影响因子: 2.9
作者:
W. J. Heitler;K. Pearson
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DOI: --
发表时间: 1989
影响因子: 2.5
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A. Chrachri;F. Clarac
通讯作者: F. Clarac
DOI: --
发表时间: 1984
期刊: Journal of Comparative Physiology
影响因子: --
作者:
R. DiCaprio;C. Fourtner
通讯作者: C. Fourtner
DOI: 10.1113/jphysiol.1978.sp012569
发表时间: 1978-01-01
影响因子: 5.5
作者:
BURROWS, M;SIEGLER, MVS
通讯作者: SIEGLER, MVS