The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior.
The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior.
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啮齿动物强迫游泳测试措施应对压力策略，而不是类似抑郁的行为。
DOI：
10.1021/acschemneuro.7b00042
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发表时间：
2017-05-17
影响因子：
5
通讯作者：
Ehlinger DG
中科院分区：
文献类型：
--
作者：
Commons KG;Cholanians AB;Babb JA;Ehlinger DG
强迫游泳测试（FST）测量应对策略，以急性不可避免的压力，从而提供了独特的洞察神经分支的压力反应。压力，特别是慢性压力，是人类抑郁症的一个促成因素，抑郁症与对压力的反应改变有关。此外，在人类中有效的抗抑郁药物通常会促进FST中的积极应对策略。因此，FST中的被动应对已大致等同于抑郁症，通常被称为“类似抑郁症”的行为。这个术语过度简化了复杂的生物学，并歪曲了FST的实用性和局限性。FST几乎没有提供结构效度或表面效度来支持将其解释为“抑郁样”行为。虽然压力应对和FST可以说与抑郁症有关，但可能有许多因素会影响压力应对策略。重要的是，还有其他神经精神疾病的特征是对压力的反应改变和难以适应变化。其中之一是自闭症谱系障碍（ASD），几种ASD的小鼠遗传模型在FST中表现出改变的压力应对策略。在这里，我们回顾的证据，认为更周到的考虑FST，更精确的术语，将有利于研究的压力和障碍的特点是改变反应的压力，其中包括但不限于抑郁症。
The forced swim test (FST) measures coping strategy to an acute inescapable stress and thus provides unique insight into the neural limb of the stress response. Stress, particularly chronic stress, is a contributing factor to depression in humans and depression is associated with altered response to stress. In addition, drugs that are effective antidepressants in humans typically promote active coping strategy in the FST. As a consequence, passive coping in the FST has become loosely equated with depression and is often referred to as “depression-like” behavior. This terminology oversimplifies complex biology and misrepresents both the utility and limitations of the FST. The FST provides little construct- or face-validity to support an interpretation as “depression-like” behavior. While stress coping and the FST are arguably relevant to depression, there are likely many factors that can influence stress coping strategy. Importantly, there are other neuropsychiatric disorders characterized by altered responses to stress and difficulty in adapting to change. One of these is autism spectrum disorder (ASD), and several mouse genetic models of ASD exhibit altered stress-coping strategies in the FST. Here we review evidence that argues a more thoughtful consideration of the FST, and more precise terminology, would benefit the study of stress and disorders characterized by altered response to stress, which include but are not limited to depression.
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DOI：
10.1016/j.pnpbp.2012.02.006
发表时间：
2012-07-02
影响因子：
5.6
作者：
Bambico, Francis Rodriguez;Hattan, Patrick R.;Gobbi, Gabriella
通讯作者：
Gobbi, Gabriella
影响因子：
3.6
作者：
Garcia-Villamisar, D.;Rojahn, J.
通讯作者：
Rojahn, J.
影响因子：
4.3
作者：
Hryhorczuk C;Sharma S;Fulton SE
通讯作者：
Fulton SE
DOI：
10.1111/gbb.12115
发表时间：
2014-03
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Brielmaier J;Senerth JM;Silverman JL;Matteson PG;Millonig JH;DiCicco-Bloom E;Crawley JN
通讯作者：
Crawley JN
影响因子：
6.8
作者：
Lim LW;Prickaerts J;Huguet G;Kadar E;Hartung H;Sharp T;Temel Y
通讯作者：
Temel Y