Metabolic disturbances connecting obesity and depression.
Metabolic disturbances connecting obesity and depression.
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DOI：
10.3389/fnins.2013.00177
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发表时间：
2013-10-07
影响因子：
4.3
通讯作者：
Fulton SE
中科院分区：
文献类型：
--
作者：
Hryhorczuk C;Sharma S;Fulton SE
肥胖会显著增加患抑郁症的几率。抑郁情绪不仅会损害动力、生活质量和整体功能，还会增加肥胖并发症的风险。腹部肥胖是一个更好的预测抑郁症和焦虑症的风险比整体脂肪量。越来越多的研究表明，由中心性肥胖引起的代谢异常导致代谢疾病，也可能是肥胖者抑郁症发病率增加的原因。如本文所述，功能失调性脂肪组织的较高质量与直接或间接涉及情绪和情绪控制的几种代谢紊乱有关。为了更好地理解肥胖症抑郁症的发展，本文综述了肥胖症，饮食和负面情绪状态之间的联系，并讨论了糖皮质激素，脂肪源性激素，胰岛素和炎症信号的改变是中心性肥胖的特征可能涉及的证据。
Obesity markedly increases the odds of developing depression. Depressed mood not only impairs motivation, quality of life and overall functioning but also increases the risks of obesity complications. Abdominal obesity is a better predictor of depression and anxiety risk than overall adipose mass. A growing amount of research suggests that metabolic abnormalities stemming from central obesity that lead to metabolic disease may also be responsible for the increased incidence of depression in obesity. As reviewed here, a higher mass of dysfunctional adipose tissue is associated with several metabolic disturbances that are either directly or indirectly implicated in the control of emotions and mood. To better comprehend the development of depression in obesity, this review pulls together select findings addressing the link between adiposity, diet and negative emotional states and discusses the evidence that alterations in glucocorticoids, adipose-derived hormones, insulin and inflammatory signaling that are characteristic of central obesity may be involved.
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影响因子：
3.7
作者：
Benedict, C;Hallschmid, M;Kern, W
通讯作者：
Kern, W
影响因子：
3.7
作者：
Chapman, Colin D.;Frey, William H., II;Craft, Suzanne;Danielyan, Lusine;Hallschmid, Manfred;Schithoth, Helgi B.;Benedict, Christian
通讯作者：
Benedict, Christian
影响因子：
3
作者：
Asakawa, A;Inui, A;Kasuga, M
通讯作者：
Kasuga, M
影响因子：
8.2
作者：
Adriaanse, M. C.;Dekker, J. M.;Pouwer, F.
通讯作者：
Pouwer, F.
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.