Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men.
Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men.
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DOI：
10.1093/ajcn/nqaa192
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发表时间：
2020-10-01
期刊：
影响因子：
--
通讯作者：
Tsintzas K
中科院分区：
文献类型：
--
作者：
Jones R;Pabla P;Mallinson J;Nixon A;Taylor T;Bennett A;Tsintzas K
改变能量摄入（EI）的时间分布和引入间歇性禁食（IF）的时期产生重要的代谢效应。将EI限制在一天的早些时候[早期限时喂养（eTRF）]是一种新型的IF。我们评估了eTRF与能量匹配对照组相比对全身和骨骼肌胰岛素和合成代谢敏感性的慢性影响。将16名健康男性（年龄23 ± 1岁; BMI 24.0 ± 0.6 kg·m − 2）分为2组，分别接受2周eTRF（n = 8）或对照/热量限制（CON：CR; n = 8）饮食。eTRF饲料可自由进食，干预在CON：CR前进行，其中提供的饲料与eTRF中观察到的EI和体重降低相匹配。eTRF期间，每日EI限制在08：00至16：00之间，这使过夜禁食时间延长了0.55 h。碳水化合物/蛋白质饮料的代谢反应进行了评估前和后干预后，12小时过夜快速。与CON：CR相比，eTRF改善了全身胰岛素敏感性[组间差异（95% CI）：1.89（0.18，3.60）; P = 0.03; η 2 p = 0.29]和骨骼肌葡萄糖摄取[组间差异（95% CI）：4266（261，8270）μ mol·min − 1·kg − 1·180 min; P = 0.04; η 2p = 0.31]和支链氨基酸（BCAA）[组间差异（95% CI）：266（77，455）nmol·min − 1·kg − 1·180 min; P = 0.01; η 2p = 0.44]。eTRF导致EI降低（约400 kcal·d − 1）和体重减轻（− 1.04 ± 0.25 kg; P = 0.01），与CON：CR（− 1.24 ± 0.35 kg; P = 0.01）相匹配。在自由生活条件下，eTRF改善全身胰岛素敏感性，增加骨骼肌葡萄糖和BCAA摄取。eTRF的代谢益处与其对体重减轻的影响无关，并且代表慢性适应，而不是最后一轮过夜禁食的影响。本试验在www.example.com上注册为NCT 03969745。
Altering the temporal distribution of energy intake (EI) and introducing periods of intermittent fasting (IF) exert important metabolic effects. Restricting EI to earlier in the day [early time-restricted feeding (eTRF)] is a novel type of IF. We assessed the chronic effects of eTRF compared with an energy-matched control on whole-body and skeletal muscle insulin and anabolic sensitivity. Sixteen healthy males (aged 23 ± 1 y; BMI 24.0 ± 0.6 kg·m−2) were assigned to 2 groups that underwent either 2 wk of eTRF (n = 8) or control/caloric restriction (CON:CR; n = 8) diet. The eTRF diet was consumed ad libitum and the intervention was conducted before the CON:CR, in which the diet was provided to match the reduction in EI and body weight observed in eTRF. During eTRF, daily EI was restricted to between 08:00 and 16:00, which prolonged the overnight fast by ∼5 h. The metabolic responses to a carbohydrate/protein drink were assessed pre- and post-interventions following a 12-h overnight fast. When compared with CON:CR, eTRF improved whole-body insulin sensitivity [between-group difference (95% CI): 1.89 (0.18, 3.60); P = 0.03; η2p = 0.29] and skeletal muscle uptake of glucose [between-group difference (95% CI): 4266 (261, 8270) μmol·min−1·kg−1·180 min; P = 0.04; η2p = 0.31] and branched-chain amino acids (BCAAs) [between-group difference (95% CI): 266 (77, 455) nmol·min−1·kg−1·180 min; P = 0.01; η2p = 0.44]. eTRF caused a reduction in EI (∼400 kcal·d−1) and weight loss (−1.04 ± 0.25 kg; P = 0.01) that was matched in CON:CR (−1.24 ± 0.35 kg; P = 0.01). Under free-living conditions, eTRF improves whole-body insulin sensitivity and increases skeletal muscle glucose and BCAA uptake. The metabolic benefits of eTRF are independent of its effects on weight loss and represent chronic adaptations rather than the effect of the last bout of overnight fast. This trial was registered at clinicaltrials.gov as NCT03969745.
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影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
2.2
作者：
CHEN, C;WILLIAMS, PF;TURTLE, JR
通讯作者：
TURTLE, JR
影响因子：
3.6
作者：
LeCheminant, James D.;Christenson, Ed;Tucker, Larry A.
通讯作者：
Tucker, Larry A.
影响因子：
6.9
作者：
Hutchison, Amy T.;Regmi, Prashant;Heilbronn, Leonie K.
通讯作者：
Heilbronn, Leonie K.
影响因子：
7.7
作者：
APARICIO, NJ;PUCHULU, FE;DEMIGUEL, R
通讯作者：
DEMIGUEL, R