Maternal or paternal suicide and offspring's psychiatric and suicide-attempt hospitalization risk.
Maternal or paternal suicide and offspring's psychiatric and suicide-attempt hospitalization risk.
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DOI：
10.1542/peds.2010-0974
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发表时间：
2010-11
期刊：
影响因子：
8
通讯作者：
Wilcox HC
中科院分区：
文献类型：
--
作者：
Kuramoto SJ;Stuart EA;Runeson B;Lichtenstein P;Långström N;Wilcox HC
我们研究了经历过父母自杀的后代与经历过父母致命事故的后代相比，需要住院治疗的精神病发病率风险是否更高，以及这种关联是否因已故父母的性别而异。1973-2003年期间，在瑞典经历母亲（n= 5，600）或父亲（n= 17，847）自杀的儿童和青少年（年龄0-17岁）使用国家纵向人口登记进行识别。采用考克斯回归模型比较自杀死亡者与事故死亡者倾向匹配的后代的精神病住院风险。与母亲意外死亡者的后代相比，母亲自杀死亡者的后代在控制了死亡者和幸存父母的精神病住院治疗后，因自杀企图住院治疗的风险增加。父亲自杀死者的后代有类似的风险住院自杀企图相比，事故死者的后代，但抑郁症和焦虑症住院的风险增加。与各自的对照组相比，母亲自杀者与父亲自杀者的后代因自杀企图住院的风险程度更大（交互作用p=0.05）[母亲死亡者的后代AHR（95%CI）= 1.80（1.19-2.74）vs.父亲死亡者的后代1.14（0.96-1.35）]。母亲自杀与后代因自杀未遂而住院的风险增加相关，超出了与母亲意外死亡相关的风险。然而，父亲自杀与自杀未遂的住院治疗无关。未来的研究应该检查那些经历母亲自杀和父亲自杀的后代之间可能存在差异的因素，包括遗传或早期环境决定因素。
We examined whether the risk for psychiatric morbidity requiring inpatient care was higher in offspring who experienced parental suicide compared to offspring who experienced parental fatal accidents, and if the association varied by the deceased parent’s gender. Children and adolescents (age 0-17 years) who experienced maternal (n=5,600) or paternal suicide (n=17,847) during 1973-2003 in Sweden were identified using national, longitudinal population-based registries. Cox regression modeling was used to compare psychiatric hospitalization risks among offspring of suicide decedents with propensity-matched offspring of accident decedents. Offspring of maternal suicide decedents had increased risk of hospitalization for suicide attempt after controlling for psychiatric hospitalization in decedents and surviving parents, compared to offspring of maternal accidental decedents. Offspring of paternal suicide decedents had similar risk of hospitalization for suicide attempt compared to offspring of accident decedents but had increased risk of hospitalization for depressive and anxiety disorders. The magnitude of risks for offspring hospitalization for suicide attempt was greater for those who experienced maternal versus paternal suicide, as compared to their respective controls (interaction p=0.05) [AHR (95%CI) = 1.80 (1.19-2.74) in offspring of maternal decedents vs. 1.14 (0.96-1.35) in offspring of paternal decedents]. Maternal suicide is associated with increased risk of hospitalization for suicide attempt in offspring, beyond the risk associated with maternal accidental death. However, paternal suicide is not associated with hospitalization for suicide attempt. Future studies should examine factors that might differ between offspring who experience maternal versus paternal suicide, including genetic or early environmental determinants.
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DOI：
10.1176/appi.ajp.2009.08081244
发表时间：
2009-07
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brent D;Melhem N;Donohoe MB;Walker M
通讯作者：
Walker M
影响因子：
6.9
作者：
Kendler, KS;Sheth, K;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
7.6
作者：
Bifulco, A;Moran, PM;Cavagin, J
通讯作者：
Cavagin, J
DOI：
10.1097/00004583-199701000-00019
发表时间：
1997-01-01
影响因子：
13.3
作者：
Pfeffer, CR;Martins, P;Jiang, H
通讯作者：
Jiang, H
影响因子：
5.4
作者：
Kessing, LV;Agerbo, E;Mortensen, PB
通讯作者：
Mortensen, PB