Photodynamic therapy induces an immune response against a bacterial pathogen.
Photodynamic therapy induces an immune response against a bacterial pathogen.
复制标题
光动力疗法诱导针对细菌病原体的免疫反应。
DOI：
10.1586/eci.12.37
复制
发表时间：
2012-07
影响因子：
4.4
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Huang YY;Tanaka M;Vecchio D;Garcia-Diaz M;Chang J;Morimoto Y;Hamblin MR
Photodynamic therapy (PDT) employs the triple combination of photosensitizers, visible light and ambient oxygen. When PDT is used for cancer, it has been observed that both arms of the host immune system (innate and adaptive) are activated. When PDT is used for infectious disease, however, it has been assumed that the direct antimicrobial PDT effect dominates. Murine arthritis caused by methicillin-resistant Staphylococcus aureus in the knee failed to respond to PDT with intravenously injected Photofrin®. PDT with intra-articular Photofrin produced a biphasic dose response that killed bacteria without destroying host neutrophils. Methylene blue was the optimum photosensitizer to kill bacteria while preserving neutrophils. We used bioluminescence imaging to noninvasively monitor murine bacterial arthritis and found that PDT with intra-articular methylene blue was not only effective, but when used before infection, could protect the mice against a subsequent bacterial challenge. The data emphasize the importance of considering the host immune response in PDT for infectious disease.
登录
查看更多内容
影响因子：
8.8
作者：
通讯作者：
--
热休克蛋白70依赖性的树突状细胞通过5-氨基乙烯酸介导的光动力治疗人胶质细胞瘤球体的体外光动力治疗。
影响因子：
8.8
作者：
Etminan, N.;Peters, C.;Lakbir, D.;Buenemann, E.;Boerger, V.;Sabel, M. C.;Haenggi, D.;Steiger, H-J;Stummer, W.;Sorg, R. V.
通讯作者：
Sorg, R. V.
影响因子：
3.3
作者：
Dai, Tianhong;Huang, Ying-Ying;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
4.5
作者：
Boumédine, RS;Roy, DC
通讯作者：
Roy, DC