Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance.
Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance.
复制标题
鼠期间心脏瓣膜发育和维持期间胶原蛋白的时间和空间表达。
DOI：
10.1002/dvdy.21719
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发表时间：
2008-10
影响因子：
2.5
通讯作者：
Lincoln, Joy
中科院分区：
文献类型：
--
作者：
Peacock, Jacqueline D.;Lu, Yinhui;Koch, Manuel;Kadler, Karl E.;Lincoln, Joy
心脏瓣膜功能是通过组织包括胶原蛋白的基质成分来实现的，但胶原蛋白在瓣膜结构中的分布并不明确。因此，我们研究了选择的纤维，网络，珠状胶原蛋白形成，和FACIT胶原蛋白在内膜垫，重塑，成熟，和成年小鼠房室心脏瓣膜的时间和空间表达。在检测的基因中，col1a1、col2a1和col3a1转录物在内膜垫中表达最高。col1a1、col1a2、col2a1和col3a1的表达仍然很高，沿着，col12a1也在重塑瓣膜中表达。成熟的新生儿瓣膜主要在限定的近端和远端区域内表达col1a1、col1a2、col3a1、col5a2、col11a1和col12a1。在成人瓣膜中，胶原蛋白分布高度区室化，在心室表面观察到ColI和ColXII，在整个瓣叶中检测到ColIII和ColVa1。总之，这些表达数据识别了发育和维持的心脏瓣膜中胶原类型的模式，这可能与瓣膜结构和功能有关。
Heart valve function is achieved by organization of matrix components including collagens, yet the distribution of collagens in valvular structures is not well defined. Therefore, we examined the temporal and spatial expression of select fibril-, network-, beaded filament-forming, and FACIT collagens in endocardial cushions, remodeling, maturing, and adult murine atrioventricular heart valves. Of the genes examined, col1a1, col2a1, and col3a1 transcripts are most highly expressed in endocardial cushions. Expression of col1a1, col1a2, col2a1, and col3a1 remain high, along with col12a1 in remodeling valves. Maturing neonate valves predominantly express col1a1, col1a2, col3a1, col5a2, col11a1, and col12a1 within defined proximal and distal regions. In adult valves, collagen protein distribution is highly compartmentalized, with ColI and ColXII observed on the ventricular surface and ColIII and ColVa1 detected throughout the leaflets. Together, these expression data identify patterning of collagen types in developing and maintained heart valves, which likely relate to valve structure and function.
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影响因子：
37.8
作者：
Aikawa, E;Whittaker, P;Schoen, FJ
通讯作者：
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影响因子：
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