Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.
Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.
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产时剂量预防艾滋病毒母婴传播后血浆奈韦拉平暴露的临床和遗传决定因素。
DOI：
10.1093/infdis/jit223
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
McMahon,De
中科院分区：
文献类型：
--
作者：
Vardhanabhuti,Saran;Acosta,EdwardP;Ribaudo,HeatherJ;Severe,Patrice;Lalloo,Umesh;Kumarasamy,Nagalingeshwaran;Taulo,Frank;Kabanda,Joseph;Oneko,Olola;Ive,Prudence;Sambarey,Pradeep;Chan,EllenS;Hitti,Jane;Hong,Francis;McMahon,De
Objective.Nevirapine is metabolized by cytochrome P450 (CYP) 2B6 and CYP3A4. We characterized relationships between clinical parameters, human genetics, pharmacokinetics, and human immunodeficiency virus type 1 (HIV-1) drug resistance mutations in pregnant women following single-dose intrapartum nevirapine.Methods.In AIDS Clinical Trials Group study A5207, women received nevirapine at onset of labor and were randomly assigned to receive lamivudine/zidovudine, emtricitabine/tenofovir, or lopinavir/ritonavir for 7 or 21 days. Plasma nevirapine level was quantified on postpartum day 1 and on weeks 1, 3, and 5. We assayed 214 polymorphisms inCYP2B6and other genes and evaluated associations with pharmacokinetic parameters, including elimination constant, time to protein-adjusted 50% inhibitory concentration (IC50), and week 5 nevirapine level below the quantification limit.Results.Among 301 women with evaluable pharmacokinetic and genotype data, lower body mass index and random assignment to receive lopinavir/ritonavir were associated with more rapid nevirapine elimination. Among those of African ancestry, longer time to IC50was associated withCYP2B6983T→C (P= .004) but not withCYP2B6516G→T (P= .8). Among Indians, slower nevirapine elimination was associated withCYP2B6516G→T (P= .04). Emergent resistance was infrequent and not associated with pharmacokinetics orCYP2B6genotype.Conclusions.The effects on plasma drug exposure following single-dose nevirapine may be greater forCYP2B6983T→C than for 516G→T and are less pronounced than at steady state.
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影响因子：
3.8
作者：
Paupy, C;Girod, R;Failloux, AB
通讯作者：
Failloux, AB
产时替诺福韦和恩曲他滨可降低单剂量奈韦拉平选择的低浓度耐药性，用于围产期 HIV 预防。
影响因子：
1.5
作者：
Chi,BenjaminH;Ellis,GiovaninaM;Chintu,Namwinga;Cantrell,RonaldA;Sinkala,Moses;Aldrovandi,GraceM;Warrier,Ranjit;Mbewe,Felistas;Nakamura,Kyle;Stringer,ElizabethM;Frenkel,LisaM;Stringer,JeffreySA
通讯作者：
Stringer,JeffreySA
影响因子：
2.2
作者：
Uttayamakul S;Likanonsakul S;Manosuthi W;Wichukchinda N;Kalambaheti T;Nakayama EE;Shioda T;Khusmith S
通讯作者：
Khusmith S
DOI：
10.1086/597125
发表时间：
2009-03-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Haas DW;Gebretsadik T;Mayo G;Menon UN;Acosta EP;Shintani A;Floyd M;Stein CM;Wilkinson GR
通讯作者：
Wilkinson GR
DOI：
10.1097/01.qai.0000167154.37357.f9
发表时间：
2005-08-01
影响因子：
3.6
作者：
Muro, E;Droste, JAH;Burger, DM
通讯作者：
Burger, DM