Heat shock protein 10 (Hsp10) in immune-related diseases: one coin, two sides.
Heat shock protein 10 (Hsp10) in immune-related diseases: one coin, two sides.
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免疫相关疾病中的热休克蛋白 10 (Hsp10)：一枚硬币，两面。
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Huang B
中科院分区：
文献类型：
--
作者：
Hu L;Cai W;Liu J;Huang B
热休克蛋白10（Heat shock protein 10，Hsp 10）是一种线粒体蛋白伴侣，在真核生物中广泛存在于细胞质、细胞表面、细胞外间隙和外周血中。在功能上，除了参与与Hsp60相关的线粒体蛋白质折叠外，Hsp10似乎与妊娠、癌症和自身免疫抑制有关。Hsp10在妊娠早期即能释放到外周血中，被称为早孕因子（EPF），在妊娠生态位的形成中起着重要作用。在恶性疾病中，Hsp10通常在恶性细胞的胞浆中异常表达，并进一步释放到细胞外空间，从而从多个方面产生促肿瘤作用。此外，不同于其他热休克蛋白成员，其可溶性形式被免疫细胞识别为危险信号并触发免疫应答，然而，Hsp 10在释放后被设计为通过限制免疫应答的抑制信号。本文综述了Hsp10参与从基本蛋白分子折叠到妊娠、癌症和自身免疫性疾病等多种生理和病理过程，强调了Hsp10的定位对分子功能发挥的重要性。
Heat shock protein 10 (Hsp10) in eukaryotes, originally identified as a mitochondrial chaperone, now is also known to be present in cytosol, cell surface, extracellular space and peripheral blood. Functionally besides participating in mitochondrial protein folding in association with Hsp60, Hsp10 appears to be related to pregnancy, cancer and autoimmune inhibition. Hsp10 can be released to peripheral blood at very early time point of pregnancy and given another name called early pregnancy factor (EPF), which seems to play a critical role in developing a pregnant niche. In malignant disorders, Hsp10 is usually abnormally expressed in the cytosol of malignant cells and further released to extracellular space, resulting in tumor-promoting effect from various aspects. Furthermore, distinct from other heat shock protein members, whose soluble form is recognized as danger signal by immune cells and triggers immune responses, Hsp10 after release, however, is designed to be an inhibitory signal by limiting immune response. This review discusses how Hsp10 participates in various physiological and pathological processes from basic protein molecule folding to pregnancy, cancer and autoimmune diseases, and emphasizes how important the location is for the function exertion of a molecule.
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