Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury.
Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury.
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DOI：
10.1016/j.expneurol.2016.08.009
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发表时间：
2017-01
影响因子：
5.3
通讯作者：
Lepore, Angelo C.
中科院分区：
文献类型：
--
作者：
Charsar, Brittany A.;Urban, Mark W.;Lepore, Angelo C.
细胞移植的治疗效果已在许多中枢神经系统 (CNS) 疾病中得到评估，包括脊髓疾病，如创伤性脊髓损伤 (SCI)。细胞移植有望保持和/或恢复正常功能，可针对多种治疗机制，包括替代丢失或受损的中枢神经系统细胞类型、促进轴突再生或发芽、神经保护、免疫反应调节以及神经营养因子等基因产物的递送等。尽管在 SCI 模型移植领域开展了大量工作，但对于利用细胞移植的治疗潜力来保护 SCI 后呼吸功能的关注有限，尽管肺部损害在这种破坏性疾病的患者预后中发挥着关键作用。在这里，我们将回顾数量有限的研究，这些研究证明了多种细胞类型的椎管内移植对于解决 SCI 呼吸功能障碍的治疗潜力。
The therapeutic benefit of cell transplantation has been assessed in a host of central nervous system (CNS) diseases, including disorders of the spinal cord such as traumatic spinal cord injury (SCI). The promise of cell transplantation to preserve and/or restore normal function can be aimed at a variety of therapeutic mechanisms, including replacement of lost or damaged CNS cell types, promotion of axonal regeneration or sprouting, neuroprotection, immune response modulation, and delivery of gene products such as neurotrophic factors, amongst other possibilities. Despite significant work in the field of transplantation in models of SCI, limited attention has been directed at harnessing the therapeutic potential of cell grafting for preserving respiratory function after SCI, despite the critical role pulmonary compromise plays in patient outcome in this devastating disease. Here, we will review the limited number of studies that have demonstrated the therapeutic potential of intraspinal transplantation of a variety of cell types for addressing respiratory dysfunction in SCI.
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