Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study.
Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study.
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DOI：
10.1136/bmj-2022-070695
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发表时间：
2022-08-02
影响因子：
105.7
通讯作者：
Nafilyan, Vahe
中科院分区：
文献类型：
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作者：
Ward, Isobel L.;Bermingham, Charlotte;Ayoubkhani, Daniel;Gethings, Owen J.;Pouwels, Koen B.;Yates, Thomas;Khunti, Kamlesh;Hippisley-Cox, Julia;Banerjee, Amitava;Walker, Ann Sarah;Nafilyan, Vahe
评估omicron BA.1与delta（B.1.617.2）感染后COVID-19死亡的风险。回顾性队列研究。英国英格兰，由二零二一年十二月一日至二零二一年十二月三十日。1 035 149名年龄在18-100岁之间的人，在国家监测方案下对SARS-CoV-2检测呈阳性，并被确定为omicron BA.1或delta兼容的感染。主要结局指标是从死亡证明记录中确定的新冠肺炎死亡人数。感兴趣的暴露是从社区进行的NHS测试和微量PCR阳性测试（支柱2）中鉴定的SARS-CoV-2变体，并由Lighthouse实验室进行分析。原因特异性考克斯比例风险回归模型（删失非COVID-19死亡）根据性别、年龄、疫苗接种状态、既往感染、日历时间、种族、多重剥夺等级指数、家庭剥夺、大学学位、关键工作人员身份、出生国、主要语言、地区、残疾和合并症进行调整。还研究了变异与性别、年龄、疫苗接种状态和合并症之间的相互作用。在对广泛的潜在混杂因素进行调整后，omicron BA.1的新冠肺炎死亡风险比delta低66%（95%置信区间为54%至75%）。与Delta相比，Omicron在18-59岁人群中的COVID-19死亡风险降低更为明显（死亡人数：δ =46，omicron=11;风险比0.14，95%置信区间0.07 - 0.27）（死亡人数：delta=113，omicron=135;风险比0.44，95%置信区间0.32至0.61，P<0.0001）。没有证据表明变体和合并症数量之间的风险存在差异。结果支持早期的研究，显示与Delta相比，omicron BA.1在住院方面的感染严重程度降低。这项研究扩展了这项研究，还显示与delta变体相比，omicron变体的covid-19死亡风险降低。
To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Retrospective cohort study. England, United Kingdom, from 1 December 2021 to 30 December 2021. 1 035 149 people aged 18-100 years who tested positive for SARS-CoV-2 under the national surveillance programme and had an infection identified as omicron BA.1 or delta compatible. The main outcome measure was covid-19 death as identified from death certification records. The exposure of interest was the SARS-CoV-2 variant identified from NHS Test and Trace PCR positive tests taken in the community (pillar 2) and analysed by Lighthouse laboratories. Cause specific Cox proportional hazard regression models (censoring non-covid-19 deaths) were adjusted for sex, age, vaccination status, previous infection, calendar time, ethnicity, index of multiple deprivation rank, household deprivation, university degree, keyworker status, country of birth, main language, region, disability, and comorbidities. Interactions between variant and sex, age, vaccination status, and comorbidities were also investigated. The risk of covid-19 death was 66% lower (95% confidence interval 54% to 75%) for omicron BA.1 compared with delta after adjusting for a wide range of potential confounders. The reduction in the risk of covid-19 death for omicron compared with delta was more pronounced in people aged 18-59 years (number of deaths: delta=46, omicron=11; hazard ratio 0.14, 95% confidence interval 0.07 to 0.27) than in those aged ≥70 years (number of deaths: delta=113, omicron=135; hazard ratio 0.44, 95% confidence interval 0.32 to 0.61, P<0.0001). No evidence of a difference in risk was found between variant and number of comorbidities. The results support earlier studies showing a reduction in severity of infection with omicron BA.1 compared with delta in terms of hospital admission. This study extends the research to also show a reduction in the risk of covid-19 death for the omicron variant compared with the delta variant.
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DOI：
10.1016/s1473-3099(21)00475-8
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Twohig KA;Nyberg T;Zaidi A;Thelwall S;Sinnathamby MA;Aliabadi S;Seaman SR;Harris RJ;Hope R;Lopez-Bernal J;Gallagher E;Charlett A;De Angelis D;Presanis AM;Dabrera G;COVID-19 Genomics UK (COG-UK) consortium
通讯作者：
COVID-19 Genomics UK (COG-UK) consortium
DOI：
10.1016/s0140-6736(22)00017-4
发表时间：
2022-01-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Wolter N;Jassat W;Walaza S;Welch R;Moultrie H;Groome M;Amoako DG;Everatt J;Bhiman JN;Scheepers C;Tebeila N;Chiwandire N;du Plessis M;Govender N;Ismail A;Glass A;Mlisana K;Stevens W;Treurnicht FK;Makatini Z;Hsiao NY;Parboosing R;Wadula J;Hussey H;Davies MA;Boulle A;von Gottberg A;Cohen C
通讯作者：
Cohen C
与SARS-COV-2血统相关的死亡率和重症监护病房在英格兰B.1.1.7：一项观察队列研究。
DOI：
10.1016/s1473-3099(21)00318-2
发表时间：
2021-11
期刊：
The Lancet. Infectious diseases
影响因子：
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作者：
Patone M;Thomas K;Hatch R;Tan PS;Coupland C;Liao W;Mouncey P;Harrison D;Rowan K;Horby P;Watkinson P;Hippisley-Cox J
通讯作者：
Hippisley-Cox J
DOI：
10.1016/s0140-6736(22)00462-7
发表时间：
2022-04-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nyberg T;Ferguson NM;Nash SG;Webster HH;Flaxman S;Andrews N;Hinsley W;Bernal JL;Kall M;Bhatt S;Blomquist P;Zaidi A;Volz E;Aziz NA;Harman K;Funk S;Abbott S;COVID-19 Genomics UK (COG-UK) consortium;Hope R;Charlett A;Chand M;Ghani AC;Seaman SR;Dabrera G;De Angelis D;Presanis AM;Thelwall S
通讯作者：
Thelwall S
影响因子：
64.8
作者：
通讯作者：
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