Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study.
Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study.
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DOI：
10.3389/fendo.2023.1266692
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
丙氨酸氨基转移酶（ALT）和高密度脂蛋白胆固醇（HDL-C）与体内葡萄糖稳态密切相关，本研究的主要目的是探讨中国人群中ALT/HDL-C比值（ALT/HDL-C比值）与糖尿病风险的关系。目前的研究包括116，251名接受健康体检的参与者，研究终点定义为新发糖尿病的诊断。采用多变量考克斯回归模型和受试者操作特征曲线评估ALT/HDL-C比值与糖尿病发病的相关性。在平均3.10年的观察期内，共有2，674名（2.3%）参与者被诊断为新发糖尿病，其中男性1，883名（1.62%），女性791名（0.68%）。在完全校正混杂因素后，我们发现ALT/HDL-C比值与糖尿病风险之间存在显著正相关[风险比1.06，95%置信区间：1.05，1.06]，并且这种相关性在男性、肥胖个体[体重指数≥ 28 kg/m2]和年龄< 60岁的个体中显著更高（所有P相互作用< 0.05）。此外，在中国人群中，ALT/HDL-C比值在预测糖尿病方面明显优于其组分ALT和HDL-C。在中国人群中，ALT/HDL-C比值与糖尿病风险呈正相关，并且这种关系在男性、肥胖个体和年龄小于60岁的个体中显著更强。
Both alanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are closely related to glucose homeostasis in the body, and the main objective of this study was to investigate the association between ALT to HDL-C ratio (ALT/HDL-C ratio) and the risk of diabetes in a Chinese population. The current study included 116,251 participants who underwent a healthy physical examination, and the study endpoint was defined as a diagnosis of new-onset diabetes. Multivariate Cox regression models and receiver operator characteristic curves were used to assess the association of the ALT/HDL-C ratio with diabetes onset. During the average observation period of 3.10 years, a total of 2,674 (2.3%) participants were diagnosed with new-onset diabetes, including 1,883 (1.62%) males and 791 (0.68%) females. After fully adjusting for confounding factors, we found a significant positive association between the ALT/HDL-C ratio and the risk of diabetes [Hazard ratios 1.06, 95% confidence intervals: 1.05, 1.06], and this association was significantly higher in males, obese individuals [body mass index ≥ 28 kg/m2] and individuals aged < 60 years (All P interaction < 0.05). In addition, the ALT/HDL-C ratio was significantly better than its components ALT and HDL-C in predicting diabetes in the Chinese population. There was a positive relationship between ALT/HDL-C ratio and diabetes risk in the Chinese population, and this relationship was significantly stronger in males, obese individuals, and individuals younger than 60 years old.
影响因子：
3.9
作者：
Nakajima K;Igata M;Higuchi R;Tanaka K;Mizusawa K;Nakamura T
通讯作者：
Nakamura T