To Kill or to Be Killed: How Does the Battle between the UPS and Autophagy Maintain the Intracellular Homeostasis in Eukaryotes?
To Kill or to Be Killed: How Does the Battle between the UPS and Autophagy Maintain the Intracellular Homeostasis in Eukaryotes?
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DOI：
10.3390/ijms24032221
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发表时间：
2023-01-22
影响因子：
5.6
通讯作者：
Hua, Zhihua
中科院分区：
文献类型：
--
作者：
Yu, Peifeng;Hua, Zhihua
关键词：
泛素- 26s蛋白酶体系统和自噬是真核生物编码的两种主要蛋白质降解机制。在正常生长条件下，UPS负责短寿命和/或可溶性错误折叠蛋白的周转，而自噬-溶酶体/空泡蛋白降解机制在应激条件下被激活，以去除细胞质和受损细胞器中可溶性或不溶性聚集体形式的长寿命蛋白。最近的发现表明，这两个看似独立的系统在维持蛋白质组稳态方面具有综合功能。其中一种整合表现为它们的相互降解，其中76个氨基酸的小肽泛素作为中央信号枢纽起着重要作用。本文就酵母菌和哺乳动物向植物转化蛋白酶体和自噬体的结构组织、生物物理状态和转化水平等方面的活性调控作一综述。通过全面的文献研究，我们提出了有待解决的困惑问题，并提出了令人兴奋的新研究方向，这些方向可能揭示蛋白质降解生物学功能的分子机制。
The ubiquitin-26S proteasome system and autophagy are two major protein degradation machineries encoded in all eukaryotic organisms. While the UPS is responsible for the turnover of short-lived and/or soluble misfolded proteins under normal growth conditions, the autophagy-lysosomal/vacuolar protein degradation machinery is activated under stress conditions to remove long-lived proteins in the forms of aggregates, either soluble or insoluble, in the cytoplasm and damaged organelles. Recent discoveries suggested an integrative function of these two seemly independent systems for maintaining the proteome homeostasis. One such integration is represented by their reciprocal degradation, in which the small 76-amino acid peptide, ubiquitin, plays an important role as the central signaling hub. In this review, we summarized the current knowledge about the activity control of proteasome and autophagosome at their structural organization, biophysical states, and turnover levels from yeast and mammals to plants. Through comprehensive literature studies, we presented puzzling questions that are awaiting to be solved and proposed exciting new research directions that may shed light on the molecular mechanisms underlying the biological function of protein degradation.
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影响因子：
16.6
作者：
Choi WH;de Poot SA;Lee JH;Kim JH;Han DH;Kim YK;Finley D;Lee MJ
通讯作者：
Lee MJ
影响因子：
8.6
作者：
Chojnacki M;Mansour W;Hameed DS;Singh RK;El Oualid F;Rosenzweig R;Nakasone MA;Yu Z;Glaser F;Kay LE;Fushman D;Ovaa H;Glickman MH
通讯作者：
Glickman MH
DOI：
10.1073/pnas.1615455113
发表时间：
2016-11-22
影响因子：
11.1
作者：
Cohen-Kaplan, Victoria;Livneh, Ido;Ciechanover, Aaron
通讯作者：
Ciechanover, Aaron
DOI：
10.3390/plants10020246
发表时间：
2021-01-27
期刊：
Plants (Basel, Switzerland)
影响因子：
--
作者：
Doroodian P;Hua Z
通讯作者：
Hua Z
影响因子：
11.8
作者：
Antonioli, Manuela;Albiero, Federica;Fimia, Gian Maria
通讯作者：
Fimia, Gian Maria