The Ubiquitin Switch in Plant Stress Response.

The Ubiquitin Switch in Plant Stress Response.
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DOI:
10.3390/plants10020246
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发表时间:
2021-01-27
期刊:
Plants (Basel, Switzerland)
影响因子:
--
通讯作者:
Hua Z
Hua Z
中科院分区:
其他
文献类型:
--
作者:
Doroodian P;Hua Z

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泛素是所有真核生物共有的76个氨基酸的多肽。它作为一个后修饰标记共价连接到一个大的队列,但定义不明确的蛋白质底物。所产生的泛素化蛋白质可以迅速改变其活动,细胞定位,或营业额通过26 S蛋白酶体,如果他们不再需要或异常。这种选择性修饰对于许多信号转导途径是必不可少的,特别是在那些通过快速增强或淬灭输出而与应激反应相关的信号转导途径中。因此,这种修饰系统,即所谓的泛素-26 S蛋白酶体系统(UPS),在过去的二十年中引起了植物研究界的关注,因为它在植物非生物和生物胁迫反应中的作用。通过植物激素的直接或间接介导,UPS选择性地降解胁迫信号中的关键组分,以负或正调节植物对给定刺激的响应。因此,多年来,受到严格管制的信令网络已变得备受关注。全球气候的不断变化既要求开发新的作物以科普快速变化的环境,也要求有新的知识来调查生态系统的动态。本文综述了泛素是如何调控植物逆境响应的,并提出了进一步研究这一系统的潜在途径。
Ubiquitin is a 76 amino acid polypeptide common to all eukaryotic organisms. It functions as a post-translationally modifying mark covalently linked to a large cohort of yet poorly defined protein substrates. The resulting ubiquitylated proteins can rapidly change their activities, cellular localization, or turnover through the 26S proteasome if they are no longer needed or are abnormal. Such a selective modification is essential to many signal transduction pathways particularly in those related to stress responses by rapidly enhancing or quenching output. Hence, this modification system, the so-called ubiquitin-26S proteasome system (UPS), has caught the attention in the plant research community over the last two decades for its roles in plant abiotic and biotic stress responses. Through direct or indirect mediation of plant hormones, the UPS selectively degrades key components in stress signaling to either negatively or positively regulate plant response to a given stimulus. As a result, a tightly regulated signaling network has become of much interest over the years. The ever-increasing changes of the global climate require both the development of new crops to cope with rapid changing environment and new knowledge to survey the dynamics of ecosystem. This review examines how the ubiquitin can switch and tune plant stress response and poses potential avenues to further explore this system.
通过热激蛋白 90 伴侣机械调节植物同源结构域和环指结构域 1 (UHRF1) 的类泛素蛋白稳定性
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