Sleep Variability, Eating Timing Variability, and Carotid Intima-Media Thickness in Early Adulthood.
Sleep Variability, Eating Timing Variability, and Carotid Intima-Media Thickness in Early Adulthood.
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DOI：
10.1161/jaha.123.029662
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发表时间：
2023-10-03
影响因子：
5.4
通讯作者：
中科院分区：
文献类型：
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作者：
睡眠模式和进食时间的日常变化可能会扰乱昼夜节律，并与各种不良心脏代谢结果有关。然而，在亚临床阶段，睡眠模式和进食时间的变化与动脉粥样硬化发展的关系程度仍不清楚。一般健康的成年人（N=62，29.3±7.3岁，66%女性）分别通过腕部加速度计和照片辅助饮食记录完成了14天的睡眠和饮食评估。睡眠持续时间、睡眠开始、进食开始（第一次消耗热量的时间）、进食偏移（最后一次消耗热量的时间）和热量中点（消耗每日总热量的50%的时间）的变异性可操作为每个变量在14天内的SD。单独的回归模型评估了睡眠和进食变异性指标与通过超声测量的舒张末期颈动脉内膜中层厚度（CIMT）之间的横截面相关性。模型调整了年龄，性别，收缩压，睡眠时间和总能量摄入。睡眠持续时间SD和睡眠起始SD每增加60分钟，CIMT分别增加0.049±0.016 mm（P=0.003）和0.048±0.017 mm（P=0.007）。进食开始和偏移的变异性与CIMT无关;然而，热量中点SD每增加60分钟，CIMT增加0.033±0.015 mm（P=0.029）。探索性事后分析表明，睡眠持续时间SD和睡眠起始SD与CIMT的相关性强于热量中点SD。睡眠模式和进食时间的变化与成年早期亚临床动脉粥样硬化的生物标志物CIMT的临床相关增加呈正相关。
Day‐to‐day variability in sleep patterns and eating timing may disrupt circadian rhythms and has been linked with various adverse cardiometabolic outcomes. However, the extent to which variability in sleep patterns and eating timing relate to atherosclerotic development in subclinical stages remains unclear. Generally healthy adults (N=62, 29.3±7.3 years, 66% female) completed 14 days of sleep and dietary assessments via wrist accelerometry and photo‐assisted diet records, respectively. Variability in sleep duration, sleep onset, eating onset (time of first caloric consumption), eating offset (time of last caloric consumption), and caloric midpoint (time at which 50% of total daily calories are consumed) were operationalized as the SD across 14 days for each variable. Separate regression models evaluated the cross‐sectional associations between sleep and eating variability metrics with end‐diastolic carotid intima‐media thickness (CIMT) measured via ultrasonography. Models adjusted for age, sex, systolic blood pressure, sleep duration, and total energy intake. Each 60‐minute increase in sleep duration SD and sleep onset SD were associated with a 0.049±0.016 mm (P=0.003) and 0.048±0.017 mm (P=0.007) greater CIMT, respectively. Variability in eating onset and offset were not associated with CIMT; however, each 60‐minute increase in caloric midpoint SD was associated with a 0.033±0.015 mm greater CIMT (P=0.029). Exploratory post hoc analyses suggested that sleep duration SD and sleep onset SD were stronger correlates of CIMT than caloric midpoint SD. Variability in sleep patterns and eating timing are positively associated with clinically relevant increases in CIMT, a biomarker of subclinical atherosclerosis, in early adulthood.
影响因子：
1.6
作者：
Nakashima, Honoka;Noda, Akiko;Tamura, Anna;Nagai, Michiaki;Okuda, Masato;Okumura, Takahiro;Yasuma, Fumihiko;Murohara, Toyoaki
通讯作者：
Murohara, Toyoaki