Malaria risk factor assessment using active and passive surveillance data from Aceh Besar, Indonesia, a low endemic, malaria elimination setting with Plasmodium knowlesi, Plasmodium vivax, and Plasmodium falciparum.
Malaria risk factor assessment using active and passive surveillance data from Aceh Besar, Indonesia, a low endemic, malaria elimination setting with Plasmodium knowlesi, Plasmodium vivax, and Plasmodium falciparum.
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DOI：
10.1186/s12936-016-1523-z
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发表时间：
2016-09-13
期刊：
影响因子：
3
通讯作者：
Hsiang MS
中科院分区：
文献类型：
--
作者：
Herdiana H;Cotter C;Coutrier FN;Zarlinda I;Zelman BW;Tirta YK;Greenhouse B;Gosling RD;Baker P;Whittaker M;Hsiang MS
随着疟疾传播的减少，它变得更加集中于地理区域，更有可能是由于无症状和非恶性疟原虫感染。为了在这种不断变化的流行病学背景下为消除疟疾规划提供信息，有必要对疟疾感染的风险因素进行当地评估，但由于疟疾病例数量较少，这一评估具有挑战性。使用2014年至2015年在印度尼西亚亚齐贝萨地区收集的被动和主动监测数据进行了一项基于人群的横断面研究。疟疾感染定义为卫生设施报告的指示病例中聚合酶链反应（PCR）确认的有症状感染，以及反应性病例检测（RACD）中确定的无症状或有症状PCR确认的感染。通过问卷调查评估RACD中任何感染、种属特异性感染或继发病例检测的潜在危险因素，并评估相关性。被动鉴定了19例诺氏疟原虫、12例间日疟原虫和6例恶性疟原虫病例，并在RACD中筛查了1495名社区成员，其中发现了6例继发病例（1例诺氏疟原虫、3例间日疟原虫和2例恶性疟原虫，4例无症状）。与在RACD中筛查的非感染受试者相比，通过被动或主动监测发现的病例更有可能是男性（AOR 12.5，95% CI 3.0-52.1），成人（AOR 14.0，16-45岁与<15岁相比的95% CI 2.2-89.6），在上个月因任何原因去过森林（AOR 5.6，95% CI 1.3-24.2），工作场所靠近或位于森林中，需要过夜（AOR 7.9，95% CI 1.6-39.7，与不在森林附近或森林中的工作场所相比）。比较不同种属感染的受试者，在居住分区和其他人口统计学和行为因素方面观察到差异。在接受RACD筛查的受试者中，与非病例相比，病例更可能发热，并且居住在索引病例的100 m范围内。在这种情况下，指数和RACD确定的病例中的疟疾感染风险与森林暴露有关，特别是在森林中工作过夜。在低传播环境中，利用通过常规被动和主动监测获得的数据可以支持针对高风险个人的努力。
As malaria transmission declines, it becomes more geographically focused and more likely due to asymptomatic and non-falciparum infections. To inform malaria elimination planning in the context of this changing epidemiology, local assessments on the risk factors for malaria infection are necessary, yet challenging due to the low number of malaria cases. A population-based, cross-sectional study was performed using passive and active surveillance data collected in Aceh Besar District, Indonesia from 2014 to 2015. Malaria infection was defined as symptomatic polymerase chain reaction (PCR)-confirmed infection in index cases reported from health facilities, and asymptomatic or symptomatic PCR-confirmed infection identified in reactive case detection (RACD). Potential risk factors for any infection, species-specific infection, or secondary-case detection in RACD were assessed through questionnaires and evaluated for associations. Nineteen Plasmodium knowlesi, 12 Plasmodium vivax and six Plasmodium falciparum cases were identified passively, and 1495 community members screened in RACD, of which six secondary cases were detected (one P. knowlesi, three P. vivax, and two P. falciparum, with four being asymptomatic). Compared to non-infected subjects screened in RACD, cases identified through passive or active surveillance were more likely to be male (AOR 12.5, 95 % CI 3.0–52.1), adult (AOR 14.0, 95 % CI 2.2–89.6 for age 16–45 years compared to <15 years), have visited the forest in the previous month for any reason (AOR 5.6, 95 % CI 1.3–24.2), and have a workplace near or in the forest and requiring overnight stays (AOR 7.9, 95 % CI 1.6–39.7 compared to workplace not near or in the forest). Comparing subjects with infections of different species, differences were observed in sub-district of residence and other demographic and behavioural factors. Among subjects screened in RACD, cases compared to non-cases were more likely to be febrile and reside within 100 m of the index case. In this setting, risk of malaria infection in index and RACD identified cases was associated with forest exposure, particularly overnights in the forest for work. In low-transmission settings, utilization of data available through routine passive and active surveillance can support efforts to target individuals at high risk.
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影响因子：
--
作者：
Bursac, Zoran;Gauss, C Heath;Williams, David Keith;Hosmer, David W
通讯作者：
Hosmer, David W
在疟疾流行环境中对疟疾寄生虫血症的高度敏感性检测：在乌干达偏远诊所中新的环路介导的等温扩增试剂盒的性能。
DOI：
10.1093/infdis/jit184
发表时间：
2013-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Hopkins H;González IJ;Polley SD;Angutoko P;Ategeka J;Asiimwe C;Agaba B;Kyabayinze DJ;Sutherland CJ;Perkins MD;Bell D
通讯作者：
Bell D
影响因子：
2.3
作者：
Howe, Laura D;Hargreaves, James R;Huttly, Sharon R A
通讯作者：
Huttly, Sharon R A
DOI：
10.4269/ajtmh.2003.68.121
发表时间：
2003-04-01
影响因子：
3.3
作者：
Hawley, WA;Phillips-Howard, PA;Hightower, AW
通讯作者：
Hightower, AW
影响因子：
3.7
作者：
Aydin-Schmidt, Berit;Xu, Weiping;Martensson, Andreas
通讯作者：
Martensson, Andreas