Human hippocampal replay during rest prioritizes weakly learned information and predicts memory performance.
Human hippocampal replay during rest prioritizes weakly learned information and predicts memory performance.
复制标题
DOI：
10.1038/s41467-018-06213-1
复制
发表时间：
2018-09-25
影响因子：
16.6
通讯作者：
Norman KA
中科院分区：
文献类型：
--
作者：
Schapiro AC;McDevitt EA;Rogers TT;Mednick SC;Norman KA
海马体会在安静的休息期间重放经历，这种重放有利于随后的记忆。一个关键的开放问题是，记忆是如何优先考虑这种重放的。我们使用功能性磁共振成像（fMRI）模式分析来跟踪在清醒休息期间海马体中的项目级重放，参与者研究了15个对象并完成了记忆测试。在接下来的休息时间里，那些记忆不太好的东西被更多地重放，这表明了一个优先顺序的过程，在这个过程中，较弱的记忆最容易被遗忘的记忆被选择重放。在12小时后的第二次会议上，在休息期间更多地重播一个对象，预示着该对象的后续记忆更好。重播预测的记忆改善，只有参与者谁睡在该间隔期间。我们的研究结果提供了证据，证明人类海马体中的重放优先考虑弱学习信息，预测随后的记忆表现，并与睡眠延迟的记忆改善有关。海马体在休息期间会“重放”经历和记忆，但目前还不清楚特定记忆是如何优先重放的。在这里，作者表明，记忆不太好的信息被更频繁地重放，这表明较弱的记忆被选择重放。
The hippocampus replays experiences during quiet rest periods, and this replay benefits subsequent memory. A critical open question is how memories are prioritized for this replay. We used functional magnetic resonance imaging (fMRI) pattern analysis to track item-level replay in the hippocampus during an awake rest period after participants studied 15 objects and completed a memory test. Objects that were remembered less well were replayed more during the subsequent rest period, suggesting a prioritization process in which weaker memories—memories most vulnerable to forgetting—are selected for replay. In a second session 12 hours later, more replay of an object during a rest period predicted better subsequent memory for that object. Replay predicted memory improvement across sessions only for participants who slept during that interval. Our results provide evidence that replay in the human hippocampus prioritizes weakly learned information, predicts subsequent memory performance, and relates to memory improvement across a delay with sleep. The hippocampus is known to 'replay' experiences and memories during rest periods, but it is unclear how particular memories are prioritized for replay. Here, the authors show that information that is remembered less well is replayed more often, suggesting that weaker memories are selected for replay.
登录
查看更多内容
影响因子：
2.5
作者：
Kastner, Sabine;DeSimone, Kevin;Schneider, Keith A.
通讯作者：
Schneider, Keith A.
影响因子：
3.7
作者：
Bursley JK;Nestor A;Tarr MJ;Creswell JD
通讯作者：
Creswell JD
影响因子：
2.2
作者：
AKERSTEDT, T;GILLBERG, M
通讯作者：
GILLBERG, M
影响因子：
5.7
作者：
de Voogd, Lycia D.;Fernandez, Guillen;Hermans, Erno J.
通讯作者：
Hermans, Erno J.
影响因子：
5.6
作者：
JOHNS, MW
通讯作者：
JOHNS, MW