Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case-control study.
Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case-control study.
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变异结缔组织（关节活动过度）及其与青少年抑郁和焦虑的关系：一项基于队列的病例对照研究。
DOI：
10.1136/bmjopen-2022-066130
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发表时间：
2022-11-30
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
为了测试关节过度活动所表明的结缔组织结构的变异是否会对青少年的情绪障碍造成发育风险。基于队列的病例对照研究。来自雅芳父母与儿童纵向研究（ALSPAC）的数据被询问。6105名14岁的ALSPAC队列儿童，其中3803名在18岁时也进行了评估。在一项风险分析中，我们研究了14岁时的广泛性关节过动症（GJH）与18岁时的精神症状之间的关系。在一项关联分析中，我们研究了18岁时症状性关节过度活动综合征（JHS）的存在与国际疾病分类-10抑郁和焦虑指征（临床访谈表修订（CIS-R），焦虑敏感性指数）之间的关系。GJH在女性（n=856, 28%）中较男性（n=319, 11%）更为常见，OR: 3.20 (95% CI: 2.78 ~ 3.68)；p < 0.001)。在男性中，14岁时的GJH与18岁时的抑郁症相关(OR: 2.10 (95% CI: 1.17至3.76)；p = 0.013)。一种基础生理唤醒指数，即静息心率的升高，介导了这种效应。不论性别，18岁时JHS的诊断与抑郁症的存在相关(校正OR: 3.53 (95% CI: 1.67至7.40)；p=0.001)，焦虑障碍(校正OR: 3.14 (95% CI: 1.52 ~ 6.46)；p=0.002)，焦虑水平(B=8.08, t(3278)=3.95；p<0.001)和精神症状程度(B=5.89, t(3442)=5.50；p < 0.001)。以关节活动过度为指标的变异胶原蛋白与青春期抑郁和焦虑的出现有关，这种影响是由男性自主神经因素介导的。认识到这种联系可能会促使进一步的评估、筛查和干预，以减轻精神疾病的发展和改善健康结果。
To test whether variant connective tissue structure, as indicated by the presence of joint hypermobility, poses a developmental risk for mood disorders in adolescence. Cohort-based case–control study. Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were interrogated. 6105 children of the ALSPAC cohort at age 14 years old, of whom 3803 also were assessed when aged 18 years. In a risk analysis, we examined the relationship between generalised joint hypermobility (GJH) at age 14 years with psychiatric symptoms at age 18 years. In an association analysis, we examined the relationship between presence of symptomatic joint hypermobility syndrome (JHS) and International Classification of Diseases-10 indication of depression and anxiety (Clinical Interview Schedule Revised (CIS-R), Anxiety Sensitivity Index) at age 18 years. GJH was more common in females (n=856, 28%) compared with males (n=319, 11%; OR: 3.20 (95% CI: 2.78 to 3.68); p<0.001). In males, GJH at age 14 years was associated with depression at 18 years (OR: 2.10 (95% CI: 1.17 to 3.76); p=0.013). An index of basal physiological arousal, elevated resting heart rate, mediated this effect. Across genders, the diagnosis of JHS at age 18 years was associated with the presence of depressive disorder (adjusted OR: 3.53 (95% CI: 1.67 to 7.40); p=0.001), anxiety disorder (adjusted OR: 3.14 (95% CI: 1.52 to 6.46); p=0.002), level of anxiety (B=8.08, t(3278)=3.95; p<0.001) and degree of psychiatric symptomatology (B=5.89, t(3442)=5.50; p<0.001). Variant collagen, indexed by joint hypermobility, is linked to the emergence of depression and anxiety in adolescence, an effect mediated by autonomic factors in males. Recognition of this association may motivate further evaluation, screening and interventions to mitigate development of psychiatric disorders and improve health outcomes.
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影响因子：
4.3
作者：
Eccles JA;Owens AP;Mathias CJ;Umeda S;Critchley HD
通讯作者：
Critchley HD
影响因子：
7
作者：
Bulbena, Antoni;Gago, Jordi;Vilarroya, Oscar
通讯作者：
Vilarroya, Oscar
关节过度运动可以将神经疾病与动作障碍和疼痛联系起来。
影响因子：
4.7
作者：
Csecs JLL;Iodice V;Rae CL;Brooke A;Simmons R;Quadt L;Savage GK;Dowell NG;Prowse F;Themelis K;Mathias CJ;Critchley HD;Eccles JA
通讯作者：
Eccles JA
DOI：
10.1097/dbp.0000000000000577
发表时间：
2018-07-01
影响因子：
2.4
作者：
Ezpeleta, Lourdes;Blas Navarro, Jose;Bulbena, Antoni
通讯作者：
Bulbena, Antoni
影响因子：
5.9
作者：
Gazit, Y;Nahir, AM;Jacob, G
通讯作者：
Jacob, G