Natural killer cell development and maturation in aged mice.
Natural killer cell development and maturation in aged mice.
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DOI：
10.1016/j.mad.2013.11.007
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发表时间：
2014-01
影响因子：
5.3
通讯作者：
Gardner, Elizabeth M.
中科院分区：
文献类型：
--
作者：
Beli, Eleni;Duriancik, David M.;Clinthorne, Jonathan F.;Lee, Taehyung;Kim, Sungjin;Gardner, Elizabeth M.
衰老对自然杀伤细胞动态平衡的影响在人类或动物模型中还没有得到很好的研究。我们比较了年轻和老年小鼠的自然杀伤(NK)细胞，以调查与年龄相关的NK细胞分布和发育缺陷。我们的发现表明，衰老小鼠周围组织中的NK细胞减少，但骨髓中的NK细胞没有减少。外周NK细胞减少是由于最成熟的CD11b+CD2 7−NK细胞减少所致。未发现细胞凋亡可以解释成熟NK细胞的这种特异性减少。对骨髓中NK细胞发育的分析表明，衰老的NK细胞在发育的早期阶段进展正常，但有一小部分老龄的NK细胞达到了最终成熟。老年骨髓中较低成熟的NK细胞与未成熟NK细胞的增殖减少有关。我们认为，高龄损害了NK细胞的骨髓成熟，可能影响了外周组织中NK细胞的动态平衡。这些NK细胞成熟状态的改变对高龄小鼠的NK细胞功能有重要影响：老年小鼠外周组织中成熟的循环NK细胞减少，影响其巡逻和清除癌细胞和病毒感染细胞的整体能力。
The effect of aging on natural killer cell homeostasis is not well studied in humans or in animal models. We compared natural killer (NK) cells from young and aged mice to investigate age-related defects in NK cell distribution, and development. Our findings indicate aged mice have reduced NK cells in most peripheral tissues, but not in bone marrow. Reduction of NK cells in periphery was attributed to a reduction of the most mature CD11b+ CD27− NK cells. Apoptosis was not found to explain this specific reduction of mature NK cells. Analysis of NK cell development in bone marrow revealed that aged NK cells progress normally through early stages of development, but a smaller percentage of aged NK cells achieved terminal maturation. Less mature NK cells in aged bone marrow correlated with reduced proliferation of immature NK cells. We propose advanced age impairs bone marrow maturation of NK cells, possibly affecting homeostasis of NK cells in peripheral tissues. These alterations in NK cell maturational status have critical consequences for NK cell function in advanced age: reduction of the mature circulating NK cells in peripheral tissues of aged mice affects their overall capacity to patrol and eliminate cancerous and viral infected cells.
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DOI：
10.4161/cc.8.1.7291
发表时间：
2009-01-01
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Ramesh S;Wildey GM;Howe PH
通讯作者：
Howe PH
影响因子：
3.9
作者：
Borrego, F;Alonso, MC;Solana, R
通讯作者：
Solana, R
影响因子：
5.3
作者：
Plett, A;Murasko, DM
通讯作者：
Murasko, DM
影响因子：
4.3
作者：
VITALE, M;ZAMAI, L;PAPA, S
通讯作者：
PAPA, S
影响因子：
5.3
作者：
Beli, Eleni;Clinthorne, Jonathan F.;Duriancik, David M.;Hwang, Ilwoong;Kim, Sungjin;Gardner, Elizabeth M.
通讯作者：
Gardner, Elizabeth M.