Calcium dynamics encode the magnitude of a graded memory underlying sensorimotor adaptation.

Calcium dynamics encode the magnitude of a graded memory underlying sensorimotor adaptation.
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钙动力学对感觉运动适应的分级记忆的大小进行编码。

DOI:
10.1152/jn.00109.2010
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发表时间:
2010
影响因子:
2.5
通讯作者:
Zakon,HaroldH
Zakon,HaroldH
中科院分区:
医学3区
文献类型:
--
作者:
Dembrow,NikolaiC;Pettit,DianaL;Zakon,HaroldH

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尽管许多形式的记忆在其强度和/或持久性方面是分级的,但Ca 2+在诱导记忆的神经相关物中的作用经常被描述为二元术语。我们发现,Ca 2+动力学编码的大小的感觉运动适应的弱电鱼的输出。这种记忆的神经相关性是突触诱导的Ca 2+依赖性增强神经元的内在兴奋性,负责设置的突触输出。诱导过程中Ca 2+的变化准确地预测了在广泛的刺激范围内这种分级记忆的大小。因此,尽管操作时间从几秒到几十分钟不等,分级记忆的编码可以通过相对简单的细胞机制来介导。
The role of Ca2+in the induction of neural correlates of memory has frequently been described in binary terms despite the fact that many forms of memory are graded in their strength and/or persistence. We find that Ca2+dynamics encode the magnitude of sensorimotor adaptation of the electromotor output in a weakly electric fish. The neural correlate of this memory is a synaptically induced Ca2+-dependent enhancement of intrinsic excitability of neurons responsible for setting the electromotor output. Changes in Ca2+during induction accurately predict the magnitude of this graded memory over a wide range of stimuli. Thus despite operating over a range from seconds to tens of minutes, the encoding of graded memory can be mediated by a relatively simple cellular mechanism.
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