Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam.
Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam.
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DOI：
10.1016/j.ijid.2021.09.016
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Mulholland K
中科院分区：
文献类型：
--
作者：
Tuan LA;Prem K;Pham QD;Toh ZQ;Tran HP;Nguyen PD;Mai CTN;Ly LTK;Cao V;Le-Ha TD;Tuan NA;Jit M;Bright K;Brisson M;Nguyen TV;Garland S;Anh DD;Trang NV;Mulholland K
在越南的两个城市对男男性行为者（MSM）的HPV感染进行了研究。MSM中任何HPV和HPV 16/18的患病率分别为32.3%和11.0%，男男性接触者中的高危型HPV感染与危险性行为有关一种有针对性的HPV疫苗接种策略将对越南的男男性接触者有益男男性接触者（MSM）有感染人乳头瘤病毒（HPV）的风险-相关的癌症，而公布的数据是稀缺的。这项研究确定了越南男男性接触者的HPV患病率和危险因素，为这一关键人群的HPV预防策略提供信息。2017-2018年在越南对799名16-50岁的MSM进行了横断面研究。收集有关危险行为的信息，以及HPV和肛门癌的知识;采取直肠拭子检测肛门HPV感染。使用内部聚合酶链反应和Genoflow HPV阵列检测试剂盒进行HPV检测和基因分型。研究参与者的中位年龄为25岁（范围18-52）。任何HPV和HPV 16/18感染的总体患病率分别为32.3%和11.0%。胡志明市（30.9%）的高危型HPV感染率高于河内（18.4%）。高危型HPV感染与不一致的安全套使用和药物影响下的性行为史（调整后的比值比（aOR），2.27; 95%CI，1.48-10.67）以及有多个性伴侣（aOR，1.01; 95%CI，1.00-1.02）相关。越南男男性接触者的高危肛门HPV感染与危险性行为显著相关。有针对性的HPV疫苗接种策略将对越南的MSM有很大的好处。
HPV infection in men having sex with men (MSM) was studied in two cities of Vietnam Prevalence of any HPV and HPV16/18 among MSM was 32.3% and 11.0%, respectively High-risk HPV infections in MSM were associated with risky sexual behaviours A targeted HPV vaccination strategy would be beneficial for MSM in Vietnam Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. This study determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population. A cross-sectional study of 799 MSM aged 16-50 years was conducted in Vietnam in 2017-2018. Information was collected on risk behaviours, and knowledge of HPV and anal cancer; rectal swabs were taken to detect anal HPV infection. An in-house polymerase chain reaction and Genoflow HPV array test kit were used for HPV detection and genotyping. The median age of the study participants was 25 years (range 18-52). Overall prevalence of any HPV and HPV16/18 infection was 32.3% and 11.0%, respectively. A higher prevalence of high-risk HPV infection to all 14 types tested was found in Ho Chi Minh City (30.9%) than in Hanoi (18.4%). High-risk HPV infection was associated with inconsistent condom use and history of engaging in sex under the influence of drugs (adjusted odds ratio (aOR), 2.27; 95% CI, 1.48-10.67), as well as having multiple sexual partners (aOR, 1.01; 95% CI, 1.00–1.02). High-risk anal HPV infections in Vietnamese MSM were significantly associated with risky sexual behaviours. A targeted HPV vaccination strategy would have substantial benefit for MSM in Vietnam.
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