Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat.
Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat.
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后肢收缩对猫升压和肌肉间质代谢反应的影响。
DOI：
10.1152/jappl.1998.85.4.1583
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Sinoway,LI
中科院分区：
文献类型：
--
作者：
MacLean,DA;LaNoue,KF;Gray,KS;Sinoway,LI
我们使用微透析技术测量了去大脑猫在3-和5-HZ抽动收缩时，运动升压反射的几种可能的代谢刺激物的间质浓度。收缩时心率和平均动脉压的峰值分别为20±5次/分和21±8毫米汞柱和27±9次/分和37±12毫米汞柱。所有变量在恢复10分钟后恢复到基线。在3和5赫兹刺激方案下，间质乳酸分别增加了0.41±0.15和0.56±0.16 mm，差异无统计学意义。在5赫兹组的恢复期，间质乳酸水平仍高于基线(P<；0.05)。随着刺激(P<；0.05)增加0.19±0.08和0.11±0.03 mm，3-HZ和5-HZ方案的透析液磷酸盐浓度(修正了探头恢复的变化)。两组之间没有差异。3赫兹和5赫兹条件下的静息K+浓度分别为4.0±0.1和3.9±0.1meq/L。在刺激过程中，两种条件下的透析液K+浓度均呈稳步上升趋势，3-和5-HZ条件下从安静到刺激的K+浓度增加(P<；0.05)分别为0.57±0.19和0.81±0.06meq/L，组间无差异。静息透析液pH分别为6.915±0.055和6.981±0.032，在3和5赫兹条件下分别升至7.013(P<；0.05)和7.053(P<；0.05)，然后在恢复(仅5赫兹)时变为酸性(6.905，P<；0.05)。这项研究是首次在猫身上同时测量多种骨骼肌间质代谢物和对抽动收缩的升压反应。这些数据表明，在收缩过程中，间质K+和磷酸盐，而不是乳酸和H+，可能有助于刺激细纤维肌肉传入。
We used the microdialysis technique to measure the interstitial concentration of several putative metabolic stimulants of the exercise pressor reflex during 3- and 5-Hz twitch contractions in the decerebrate cat. The peak increases in heart rate and mean arterial pressure during contraction were 20 ± 5 beats/min and 21 ± 8 mmHg and 27 ± 9 beats/min and 37 ± 12 mmHg for the 3- and 5-Hz stimulation protocols, respectively. All variables returned to baseline after 10 min of recovery. Interstitial lactate rose (P< 0.05) by 0.41 ± 0.15 and 0.56 ± 0.16 mM for the 3- and 5-Hz stimulation protocols, respectively, and were not statistically different from one another. Interstitial lactate levels remained above (P< 0.05) baseline during recovery in the 5-Hz group. Dialysate phosphate concentrations (corrected for shifts in probe recovery) rose with stimulation (P< 0.05) by 0.19 ± 0.08 and 0.11 ± 0.03 mM for the 3- and 5-Hz protocols. There were no differences between groups. The resting dialysate K+concentrations for the 3- and 5-Hz conditions were 4.0 ± 0.1 and 3.9 ± 0.1 meq/l, respectively. During stimulation the dialysate K+concentrations rose steadily for both conditions, and the increase from rest to stimulation (P< 0.05) was 0.57 ± 0.19 and 0.81 ± 0.06 meq/l for the 3- and 5-Hz conditions, respectively, with no differences between groups. Resting dialysate pH was 6.915 ± 0.055 and 6.981 ± 0.032 and rose to 7.013 (P< 0.05) and 7.053 (P< 0.05) for the 3- and 5-Hz conditions, respectively, and then became acidotic (6.905,P< 0.05) during recovery (5 Hz only). This study represents the first time simultaneous measurements of multiple skeletal muscle interstitial metabolites and pressor responses to twitch contractions have been made in the cat. These data suggest that interstitial K+and phosphate, but not lactate and H+, may contribute to the stimulation of thin fiber muscle afferents during contraction.
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DOI：
10.1172/jci115792
发表时间：
1992
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Sinoway,LI;Rea,RF;Mosher,TJ;Smith,MB;Mark,AL
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Sinoway,LI;Hill,JM;Pickar,JG;Kaufman,MP
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Kaufman,MP
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DOI：
--
发表时间：
1985
期刊：
影响因子：
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DOI：
10.1113/jphysiol.1992.sp019183
发表时间：
1992
期刊：
The Journal of Physiology
影响因子：
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G. Sjøgaard
DOI：
--
发表时间：
1971
期刊：
Journal of Physiology
影响因子：
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作者：
By J. G. Coote;S. Hilton;J. Perez
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