Frequency of lupus flare in pregnancy. The Hopkins Lupus Pregnancy Center experience.
Frequency of lupus flare in pregnancy. The Hopkins Lupus Pregnancy Center experience.
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怀孕期间狼疮发作的频率。
DOI：
10.1002/art.1780341210
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发表时间：
1991
影响因子：
--
通讯作者：
Repke,J
中科院分区：
文献类型：
--
作者：
Petri,M;Howard,D;Repke,J
为了确定妊娠是否与系统性红斑狼疮(SLE)患者红斑率的增加有关，我们前瞻性地研究了37名SLE女性的40例妊娠。这些妇女每月在霍普金斯狼疮妊娠中心接受评估。使用先前开发的定量定义来指定Flare，即，自上次就诊或在最近93天内，医生的总体评估(0-3级)的变化>；1.0。有24例(60%)的妊娠出现耀斑。红斑最常见的表现为躯体症状、肾脏受累或皮肤或关节受累。比较相同患者产后和非孕期SLE患者的红斑率，发现妊娠期红斑率显著增加(P<；0.001和P<；0.0001)。我们得出结论，妊娠期红斑狼疮是常见的，而且比非妊娠SLE患者或怀孕后相同患者的红斑狼疮发生频率明显更高。
To determine whether pregnancy is associated with an increased rate of flare in patients with systemic lupus erythematosus (SLE), we prospectively studied 40 pregnancies in 37 women with SLE. The women were evaluated on a monthly basis in the Hopkins Lupus Pregnancy Center. Flare was designated using a previously developed quantitative definition, i.e., a change of >1.0 in the physician's global assessment (scale of 0–3) since the preceding visit or during the last 93 days. Flare occurred in 24 (60%) of the pregnancies. Flares presented most commonly as constitutional symptoms, renal involvement, or involvement of skin or joints. Comparison of the rates of flare in the same patients after delivery and in nonpregnant SLE patients showed a significant increase in the rate of flare during pregnancy (P<0.001 andP<0.0001, respectively). We conclude that flare of lupus during pregnancy is common and occurs significantly more frequently than does flare in nonpregnant SLE patients or in the same patients after pregnancy.
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系统性红斑狼疮妊娠的前瞻性研究。
DOI：
10.1097/00006254-198705000-00008
发表时间：
1986
期刊：
The Journal of rheumatology
影响因子：
--
作者：
G. Mintz;J. Niz;G. Gutierrez;A. Garcia;S. Karchmer
通讯作者：
S. Karchmer
影响因子：
--
作者：
PETRI, M;GENOVESE, M;HOCHBERG, M
通讯作者：
HOCHBERG, M
影响因子：
3.9
作者：
H. Nossent;T. Swaak
通讯作者：
T. Swaak
评论 Lockshin 的文章。
影响因子：
--
作者：
A. Parke;M. Peterson;N. Rothfield
通讯作者：
N. Rothfield
影响因子：
--
作者：
P. Jungers;M. Dougados;C. Pélissier;F. Kuttenn;F. Tron;P. Lesavre;J. Bach
通讯作者：
J. Bach