The relationship between blood pressure and cognitive function.
The relationship between blood pressure and cognitive function.
复制标题
血压与认知功能的关系。
DOI：
10.1016/j.ijcrp.2021.200104
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Harada K
中科院分区：
文献类型：
--
作者：
Ishikawa J;Seino S;Kitamura A;Toba A;Toyoshima K;Tamura Y;Watanabe Y;Fujiwara Y;Inagaki H;Awata S;Shinkai S;Araki A;Harada K
尽管收缩压 (SBP) 升高与认知功能障碍相关，但随着严重的认知功能障碍，血压可能会降低；因此，我们试图确定老年受试者认知功能与收缩压之间关系的转折点。在一般人群和门诊诊所（年龄 > 65 岁）的汇总数据集中，评估了虚弱或认知功能障碍的风险 (N = 4076)，并检查了 SBP 和简易精神状态检查 (MMSE) 评分之间的关系。平均年龄为 72.5 ± 6.2 岁（男性 45.1%），收缩压为 133.0 ± 19.5 mmHg。在局部加权散点图平滑分析中，SBP 和 MMSE 分数之间的关系在 MMSE 分数为 24 分时发生变化。在认知功能保留的受试者中（MMSE ≥24 分），在调整年龄、性别、体重指数、饮酒习惯、吸烟状况、糖尿病、中风病史和老年营养指数后，MMSE 评分随着 SBP 的增加而降低（B = -0.047 每 10 mmHg 增加，P = 0.002）；然而，在认知功能降低的受试者中（MMSE <24 分），MMSE 评分的降低与 SBP 的降低相关（MMSE 评分每降低 1 分，B = 1.178，P = 0.002）。 SBP 与认知功能之间的关系在 MMSE 评分约为 24 分（轻度至中度认知功能障碍）时发生变化。在 MMSE 保留的患者中，较高的血压值与认知功能下降相关，但对于 MMSE 受损的患者而言，情况并非如此。
Although an elevated systolic blood pressure (SBP) is associated with cognitive dysfunction, BP may decrease with advanced cognitive dysfunction; therefore, we attempted to identify the turning point in the relationship between cognitive function and SBP in elderly subjects. In pooled datasets of general populations and outpatient clinics (age>65 years), in which the risk of frailty or cognitive dysfunction was assessed (N = 4076), the relationship between SBP and the Mini Mental State Examination (MMSE) score was examined. Mean age was 72.5 ± 6.2 years (male 45.1%), and SBP was 133.0 ± 19.5 mmHg. In an analysis of locally weighted scatter plot smoothing, the relationship between SBP and MMSE scores changed at an MMSE score of 24 points. In subjects with preserved cognitive function (MMSE ≥24 points), MMSE scores decreased with increases in SBP (B = −0.047 per 10 mmHg increase, P = 0.002) after adjustments for age, sex, body mass index, alcohol habit, smoking status, diabetes, a history of stroke, and the geriatric nutritional index; however, in subjects with reduced cognitive function (MMSE<24 points), decreases in the MMSE score were associated with reductions in SBP (B = 1.178 per 1 point decrease in the MMSE score, P = 0.002). The relationship between SBP and cognitive function changed at a MMSE score of approximately 24 points (mild to moderate cognitive dysfunction). In patients with preserved MMSE, higher BP values were associated with a reduction of cognitive function, but this was not a case for those with impaired MMSE.
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影响因子：
7.1
作者：
Bouillanne, O;Morineau, G;Aussel, C
通讯作者：
Aussel, C
影响因子：
4.1
作者：
Tamura Y;Ishikawa J;Fujiwara Y;Tanaka M;Kanazawa N;Chiba Y;Iizuka A;Kaito S;Tanaka J;Sugie M;Nishimura T;Kanemaru A;Shimoji K;Hirano H;Furuta K;Kitamura A;Seino S;Shinkai S;Harada K;Kyo S;Ito H;Araki A
通讯作者：
Araki A
影响因子：
3.2
作者：
Sakakura, Kenichi;Hoshide, Satoshi;Kario, Kazuomi
通讯作者：
Kario, Kazuomi
影响因子：
8.3
作者：
de Jong, Daan L. K.;de Heus, Rianne A. A.;Claassen, Jurgen A. H. R.
通讯作者：
Claassen, Jurgen A. H. R.
影响因子：
3.7
作者：
Seino S;Shinkai S;Fujiwara Y;Obuchi S;Yoshida H;Hirano H;Kim HK;Ishizaki T;Takahashi R;TMIG-LISA Research Group
通讯作者：
TMIG-LISA Research Group