Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation.
Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation.
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DOI：
10.1093/jmcb/mjac078
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发表时间：
2023-02-07
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
Thyroid hormone excess secondary to global type 3 deiodinase (DIO3) deficiency leads to increased locomotor activity and reduced adiposity, but also to concurrent alterations in parameters of the leptin–melanocortin system that would predict obesity. To distinguish the underlying contributions to the energy balance phenotype of DIO3 deficiency, we generated mice with thyroid hormone excess targeted to pro-opiomelanocortin (POMC)-expressing cells via cell-specific DIO3 inactivation. These mice exhibit a male-specific phenotype of reduced hypothalamic Pomc expression, hyperphagia, and increased activity in brown adipose tissue, with adiposity and serum levels of leptin and thyroid hormones remained normal. These male mice also manifest a marked and widespread hypothalamic reduction in the expression of bone morphogenetic receptor 1a (BMPR1A), which has been shown to cause similar phenotypes when inactivated in POMC-expressing cells. Our results indicate that developmental overexposure to thyroid hormone in POMC-expressing cells programs energy balance mechanisms in a sexually dimorphic manner by suppressing adult hypothalamic BMPR1A expression.
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影响因子：
4.8
作者：
Escámez, MJ;Guadaño-Ferraz, A;Bernal, J
通讯作者：
Bernal, J
影响因子：
4.8
作者：
Berger, Alta;Kablan, Ahmed;Chen, Min
通讯作者：
Chen, Min
影响因子：
2.9
作者：
Fekete, C;Mihály, E;Lechan, RM
通讯作者：
Lechan, RM
影响因子：
8.8
作者：
Hameed S;Patterson M;Dhillo WS;Rahman SA;Ma Y;Holton C;Gogakos A;Yeo GSH;Lam BYH;Polex-Wolf J;Fenske W;Bell J;Anastasovska J;Samarut J;Bloom SR;Bassett JHD;Williams GR;Gardiner JV
通讯作者：
Gardiner JV
影响因子：
5.2
作者：
Flamant F;Koibuchi N;Bernal J
通讯作者：
Bernal J