Genetic Constructor: An Online DNA Design Platform.

Genetic Constructor: An Online DNA Design Platform.
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Genetic Constructor:在线 DNA 设计平台。

DOI:
10.1021/acssynbio.7b00236
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发表时间:
2017
影响因子:
4.7
通讯作者:
Bates M
Bates M
中科院分区:
生物学2区
文献类型:
--
作者:
Bates M

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Genetic Constructor是一个云计算机辅助设计(CAD)应用程序,开发用于支持合成生物学家从设计意图到DNA制造和实验迭代。该平台允许用户设计,管理和导航复杂的DNA结构和文库,使用一种新的视觉语言,专注于从序列中提取的功能部分。组合文库和自动化引物设计等功能允许用户通过关注功能意图将设计与构建分开,并且设计约束有助于设计的迭代改进。插件架构使科学家和编码人员能够利用现有强大的软件并连接到DNA代工厂。该软件易于访问,平台无关,对学者免费,并提供开源社区版本。Genetic Constructor旨在使DNA设计、制造和获得合成生物学社区的工具和服务民主化。
Genetic Constructor is a cloud Computer Aided Design (CAD) application developed to support synthetic biologists from design intent through DNA fabrication and experiment iteration. The platform allows users to design, manage, and navigate complex DNA constructs and libraries, using a new visual language that focuses on functional parts abstracted from sequence. Features like combinatorial libraries and automated primer design allow the user to separate design from construction by focusing on functional intent, and design constraints aid iterative refinement of designs. A plugin architecture enables contributions from scientists and coders to leverage existing powerful software and connect to DNA foundries. The software is easily accessible and platform agnostic, free for academics, and available in an open-source community edition. Genetic Constructor seeks to democratize DNA design, manufacture, and access to tools and services from the synthetic biology community.
DOI: 10.1371/journal.pone.0018882
发表时间: 2011-04-29
期刊: PloS one
影响因子: 3.7
作者:
Bilitchenko L;Liu A;Cheung S;Weeding E;Xia B;Leguia M;Anderson JC;Densmore D
通讯作者: Densmore D
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DOI: 10.1111/1567-1364.12171
发表时间: 2015-02
影响因子: 3.2
作者:
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通讯作者: Zhao H
基因型规范语言。
DOI: --
发表时间: 2016
影响因子: 4.7
作者:
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