Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy.
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy.
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SARS-CoV-2与宿主细胞相互作用的分子机制及介入治疗
DOI：
10.1038/s41392-021-00653-w
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发表时间：
2021-06-11
影响因子：
39.3
通讯作者：
Yu F
中科院分区：
文献类型：
--
作者：
Zhang Q;Xiang R;Huo S;Zhou Y;Jiang S;Wang Q;Yu F
严重的急性呼吸综合症2（SARS-COV-2）感染引起的冠状病毒疾病大流行（COVID-19）导致全球经济和健康造成了前所未有的挫折。 SARS-COV-2具有异常高的可传播性和极为宽的组织对流。然而，负责维持这种毒力的基本分子机制仍然在很大程度上尚未探索。在本文中，我们回顾了有关SARS-COV-2如何通过各种受体（例如ACE2，Neuropilin-1，Axl和抗体–FCγR复合物）附着在宿主细胞表面上的当前知识和关键信息。我们进一步解释了其尖峰蛋白如何在蛋白酶（例如Furin，TMPRSS2和组织蛋白酶）等蛋白酶的帮助下经历从灌注到后灌注的构象转变。然后，我们回顾了具有抗SARS-COV-2活性的抗体，肽或小分子化合物的正在进行的实验研究和临床试验，并讨论了这些靶向宿主 - path剂相互作用的这些抗病毒疗法如何潜在地抑制病毒式依恋，从而减少融合肽的暴露于降低膜的融合型和六个组的构造（6-Hb）s SIX-HELIX fe nif s SIST-HELIX fe nif of SIST-HELIX fe s s SIX-HELIX fe s s SIX-HELIX。最后，快速新兴的SARS-COV-2变体的幽灵值得对广谱药物或疫苗进行认真的审查，以预防和控制COVID-19。
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback for global economy and health. SARS-CoV-2 has an exceptionally high level of transmissibility and extremely broad tissue tropism. However, the underlying molecular mechanism responsible for sustaining this degree of virulence remains largely unexplored. In this article, we review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors, such as ACE2, neuropilin-1, AXL, and antibody–FcγR complexes. We further explain how its spike (S) protein undergoes conformational transition from prefusion to postfusion with the help of proteases like furin, TMPRSS2, and cathepsins. We then review the ongoing experimental studies and clinical trials of antibodies, peptides, or small-molecule compounds with anti-SARS-CoV-2 activity, and discuss how these antiviral therapies targeting host–pathogen interaction could potentially suppress viral attachment, reduce the exposure of fusion peptide to curtail membrane fusion and block the formation of six-helix bundle (6-HB) fusion core. Finally, the specter of rapidly emerging SARS-CoV-2 variants deserves a serious review of broad-spectrum drugs or vaccines for long-term prevention and control of COVID-19 in the future.
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DOI：
10.1038/nrd1227
发表时间：
2003-11
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Acharya KR;Sturrock ED;Riordan JF;Ehlers MR
通讯作者：
Ehlers MR
DOI：
10.1074/jbc.m110.103275
发表时间：
2010-07-23
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Belouzard S;Madu I;Whittaker GR
通讯作者：
Whittaker GR
影响因子：
56.9
作者：
Cai, Yongfei;Zhang, Jun;Chen, Bing
通讯作者：
Chen, Bing
影响因子：
4.7
作者：
Alsibai, Kinan Drak
通讯作者：
Alsibai, Kinan Drak
影响因子：
5.4
作者：
Bosch, Berend Jan;Bartelink, Willem;Rottier, Peter J. M.
通讯作者：
Rottier, Peter J. M.