The Role of Phospholipid Transfer Protein in the Development of Atherosclerosis.
The Role of Phospholipid Transfer Protein in the Development of Atherosclerosis.
复制标题
DOI：
10.1007/s11883-021-00907-6
复制
发表时间：
2021-01-26
影响因子：
5.8
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Jiang XC;Yu Y
磷脂转运蛋白（PLTP）属于脂质转运蛋白家族，是循环系统中参与脂质代谢的重要蛋白质。本文综述了近年来PLTP的研究进展，涉及脂蛋白代谢和动脉粥样硬化的发生。PLTP活性影响致动脉粥样硬化和抗动脉粥样硬化脂蛋白水平。人血清PLTP活性是人类心血管疾病的危险因素，也是全因死亡率的独立预测因子。在小鼠模型中，PLTP缺乏可降低VLDL和LDL水平并减弱动脉粥样硬化，而PLTP过表达则发挥相反的作用。PLTP缺乏和过度表达均导致HDL降低，HDL具有不同的大小、炎症指数和脂质组成。此外，尽管PLTP缺陷和过表达均降低胆固醇流出能力，但这种效应对小鼠巨噬细胞胆固醇逆向转运没有影响。此外，PLTP活性与代谢综合征、血栓形成和炎症有关。PLTP可能是治疗血脂异常和动脉粥样硬化的靶点，但应注意一些潜在的脱靶效应。
Phospholipid transfer protein (PLTP), a member of lipid transfer protein family, is an important protein involved in lipid metabolism in the circulation. This article reviews recent PLTP research progresses, involving lipoprotein metabolism and atherogenesis. PLTP activity influence atherogenic and anti-atherogenic lipoprotein levels. Human serum PLTP activity is a risk factor for human cardiovascular disease and is an independent predictor of all-cause mortality. PLTP deficiency reduces VLDL and LDL levels and attenuates atherosclerosis in mouse models, while PLTP overexpression exerts an opposite effect. Both PLTP deficiency and overexpression result in reduction of HDL which has different size, inflammatory index, and lipid composition. Moreover, although both PLTP deficiency and overexpression reduce cholesterol efflux capacity, but this effect has no impact in macrophage reverse cholesterol transport in mice. Furthermore, PLTP activity is related with metabolic syndrome, thrombosis, and inflammation. PLTP could be target for the treatment of dyslipidemia and atherosclerosis, although some potential off-target effects should be noted.
登录
查看更多内容
影响因子：
5.3
作者：
Bosteen, Markus Hoybye;Svarrer, Eva Martha Madsen;Pedersen, Tanja Xenia
通讯作者：
Pedersen, Tanja Xenia
影响因子：
6
作者：
Deckert, Valerie;Kretz, Benjamin;Lagrost, Laurent
通讯作者：
Lagrost, Laurent
影响因子：
7.6
作者：
Desrumaux, Catherine;Pisoni, Amandine;Maurice, Tangui
通讯作者：
Maurice, Tangui
影响因子：
5.3
作者：
Cavusoglu, Erdal;Marmur, Jonathan D.;Chhabra, Sandeep;Hojjati, Mohammad R.;Yanamadala, Sunitha;Chopra, Vineet;Eng, Calvin;Jiang, Xian-Cheng
通讯作者：
Jiang, Xian-Cheng
影响因子：
158.5
作者：
Cuchel, Marina;Bloedon, LeAnne T.;Rader, Daniel J.
通讯作者：
Rader, Daniel J.