Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19.
Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19.
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DOI：
10.1186/s12987-022-00357-5
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发表时间：
2022-08-18
影响因子：
7.3
通讯作者：
Stipursky, Joice
中科院分区：
文献类型：
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作者：
Adesse, Daniel;Gladulich, Luis;Alvarez-Rosa, Liandra;Siqueira, Michele;Marcos, Anne Caroline;Heider, Marialice;Motta, Caroline Soares;Torices, Silvia;Toborek, Michal;Stipursky, Joice
COVID-19是由严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）引起的，由于致命性肺炎和呼吸窘迫，在世界范围内造成了毁灭性的发病率和死亡率。此外，有充分证据表明，中枢神经系统（CNS）是SARS-CoV-2的靶点，研究在COVID-19患者的大脑和脑脊液中检测到SARS-CoV-2。血脑屏障（BBB）可能是SARS-CoV-2脑感染的主要途径。在功能上，血脑屏障是由内皮细胞、周细胞、星形胶质细胞、小胶质细胞和神经元之间的相互作用产生的，它们构成了神经血管单位（NVU）。然而，目前，SARS-CoV-2与NVU的相互作用以及这一过程的结果在很大程度上是未知的。此外，年龄被描述为住院和死亡的最突出风险因素之一，以及其他合并症，如糖尿病和合并感染。本文将讨论SARS-CoV-2对NVU的影响、SARS-CoV-2受体在中枢神经系统不同细胞类型中的表达谱以及衰老在COVID-19神经系统预后中的可能作用。将特别强调线粒体功能，因为功能失调的线粒体也是炎症反应和与SARS-CoV-2感染相关的“细胞因子风暴”的强诱导剂。最后，我们将讨论治疗老年患者神经内皮功能的可能药物疗法，从而缓解与COVID-19相关的神经系统症状。
COVID-19, which is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), has resulted in devastating morbidity and mortality worldwide due to lethal pneumonia and respiratory distress. In addition, the central nervous system (CNS) is well documented to be a target of SARS-CoV-2, and studies detected SARS-CoV-2 in the brain and the cerebrospinal fluid of COVID-19 patients. The blood–brain barrier (BBB) was suggested to be the major route of SARS-CoV-2 infection of the brain. Functionally, the BBB is created by an interactome between endothelial cells, pericytes, astrocytes, microglia, and neurons, which form the neurovascular units (NVU). However, at present, the interactions of SARS-CoV-2 with the NVU and the outcomes of this process are largely unknown. Moreover, age was described as one of the most prominent risk factors for hospitalization and deaths, along with other comorbidities such as diabetes and co-infections. This review will discuss the impact of SARS-CoV-2 on the NVU, the expression profile of SARS-CoV-2 receptors in the different cell types of the CNS and the possible role of aging in the neurological outcomes of COVID-19. A special emphasis will be placed on mitochondrial functions because dysfunctional mitochondria are also a strong inducer of inflammatory reactions and the “cytokine storm” associated with SARS-CoV-2 infection. Finally, we will discuss possible drug therapies to treat neural endothelial function in aged patients, and, thus, alleviate the neurological symptoms associated with COVID-19.
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影响因子：
--
作者：
Andersson MI;Arancibia-Carcamo CV;Auckland K;Baillie JK;Barnes E;Beneke T;Bibi S;Brooks T;Carroll M;Crook D;Dingle K;Dold C;Downs LO;Dunn L;Eyre DW;Gilbert Jaramillo J;Harvala H;Hoosdally S;Ijaz S;James T;James W;Jeffery K;Justice A;Klenerman P;Knight JC;Knight M;Liu X;Lumley SF;Matthews PC;McNaughton AL;Mentzer AJ;Mongkolsapaya J;Oakley S;Oliveira MS;Peto T;Ploeg RJ;Ratcliff J;Robbins MJ;Roberts DJ;Rudkin J;Russell RA;Screaton G;Semple MG;Skelly D;Simmonds P;Stoesser N;Turtle L;Wareing S;Zambon M
通讯作者：
Zambon M
影响因子：
4.6
作者：
Bertrand L;Dygert L;Toborek M
通讯作者：
Toborek M
影响因子：
4.8
作者：
Buxbaum, JD;Liu, KN;Black, RA
通讯作者：
Black, RA
影响因子：
21.3
作者：
Bleazard, W;McCaffery, JM;Shaw, JM
通讯作者：
Shaw, JM
影响因子：
0.6
作者：
Abdelrahman, Heba S.;Safwat, Ahmed M.;Alsagheir, Mahmoud M.
通讯作者：
Alsagheir, Mahmoud M.