Lead exposure and association with angiogenic factors and hypertensive disorders of pregnancy.
Lead exposure and association with angiogenic factors and hypertensive disorders of pregnancy.
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DOI：
10.1016/j.preghy.2020.07.014
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
O'Brien K
中科院分区：
文献类型：
--
作者：
Johnson KM;Specht AJ;Hart JM;Salahuddin S;Erlinger AL;Hacker MR;Woolf AD;Hauptman M;Karumanchi SA;Wylie BJ;O'Brien K
铅暴露与妊娠期高血压疾病有关。血管生成因子，包括可溶性fms样酪氨酸激酶1（sFlt 1）和胎盘生长因子（PlGF），在先兆子痫中是异常的，但与铅水平无关。我们评估了铅暴露与血管生成因子的关系。这项横断面研究使用了妊娠≥34周的单胎妊娠的便利样本。分娩前测量血铅和血管生成因子;产后测量骨铅。我们将骨铅和血铅分为最高三分位数和最低三分位数，并使用对数二项回归来评估铅和高血管生成率之间的关联。结果是高sFlt 1与PlGF的比例和妊娠期高血压疾病的发展。我们招募了102名参与者，其中98人至少有一次导联测量和血管生成因子结果。骨铅中位数为3.8 ug/g（2.0 - 6.6），血铅中位数为0.2 ug/dL（0.2 - 0.4）。妊娠期高血压疾病的发病率为31%。当比较骨铅的最高三分位数与最低两个三分位数时，与高sFlt 1/PlGF比率或妊娠高血压疾病无关。血铅暴露也观察到类似的结果。在我们的美国人群中，铅暴露不是导致血管生成因子比率升高或妊娠期高血压疾病的重要因素。然而，在我们的人群中铅暴露是适度的，我们不能排除与妊娠期高血压疾病的关系。
Lead exposure has been associated with hypertensive disorders of pregnancy. Angiogenic factors, including soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF), are aberrant in preeclampsia, but have not been correlated with lead levels. We evaluated the association of lead exposure with angiogenic factors. This cross sectional study utilized a convenience sample of singleton pregnancies ≥34 weeks’ gestation. Blood lead and angiogenic factors were measured before delivery; bone lead was measured postpartum. We dichotomized bone and blood lead into the top tertile versus the bottom tertiles and used log-binomial regression to assess the association between lead and a high angiogenic ratio. The outcomes were high sFlt1 to PlGF ratio and development of a hypertensive disorder of pregnancy. We enrolled 102 participants, of whom 98 had at least one lead measurement and an angiogenic factor result. Median bone lead was 3.8 ug/g (2.0 – 6.6) and median blood lead was 0.2 ug/dL (0.2 – 0.4). Incidence of hypertensive disorders of pregnancy was 31%. When comparing the highest tertile of bone lead to the bottom two tertiles, there was no association with a high sFlt1/PlGF ratio or hypertensive disorders of pregnancy. Similar results were observed for the exposure of blood lead. Lead exposure was not an important contributor to an elevated angiogenic factor ratio or hypertensive disorders of pregnancy in our U.S. population. However, lead exposure was modest in our population and we cannot exclude a relationship with hypertensive disorders of pregnancy.
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影响因子：
37.8
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Goel A;Maski MR;Bajracharya S;Wenger JB;Zhang D;Salahuddin S;Shahul SS;Thadhani R;Seely EW;Karumanchi SA;Rana S
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影响因子：
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